摘要
终末期肝病长期以来一直威胁着人类健康,迄今为止,对这些疾病的治疗缺乏有效手段。同种异体器官移植已成为大多数终末期肝病患者的最后一根稻草。然而,该技术受到供体严重短缺以及免疫排斥、药物综合征、成本高昂等因素的极大限制。最近,三维 (3D) 生物打印技术的出现,连同磁共振成像 (MRI) 和计算机断层扫描 (CT) 技术,推动了该领域向肝脏疗法的快速发展。肝脏 3D 生物打印有几个基本要求。从患病肝脏的信息收集,到肝脏替代品的 3D 打印(包含主要结构、材料和功能特征),再到临床应用,合适的“生物墨水”和“生物打印机”发挥了重要作用。在这篇综述中,我们重点介绍了用于血管化和受神经支配的肝组织 3D 生物打印的先进“生物墨水”和“生物打印机”。已经强调了将胆管网络纳入生物人工肝的进一步研究。预计当肝脏 3D 生物打印的所有瓶颈问题都得到解决后,生物人工肝脏的批量(即批量)和个性化生产将使治疗终末期肝病变得非常容易。
关键词: 3D 生物打印、生物人工肝、生物墨水、生物打印机、血管化和受神经支配的组织、胆管网络。
Current Medicinal Chemistry
Title:Three-dimensional Printing-Driving Liver Therapies
Volume: 28 Issue: 33
关键词: 3D 生物打印、生物人工肝、生物墨水、生物打印机、血管化和受神经支配的组织、胆管网络。
摘要: End-stage liver diseases have long been a threat to human health, and so far, the treatment of these diseases lacks effective means. Allogenic organ transplantation has become the last straw for most of the patients with end-stage liver diseases. However, this technique has been greatly limited by the serious shortage of donors and other factors, such as immune rejection, drug syndrome, and high cost. Recently, the emergence of three-dimensional (3D) bioprinting technologies, together with the magnetic resonance imaging (MRI) and computed tomography (CT) techniques, has driven the rapid growth of this field toward liver therapies. There are several basic requirements for liver 3D bioprinting. From information collection of diseased livers, to 3D printing of liver substitutes (containing the major structural, material and functional characters), and to clinical applications, suitable ‘bioinks’ and ‘bioprinters’ have played essential roles. In this review, we highlight the advanced ‘bioinks’ and ‘bioprinters’ that have been used for vascularized and innervated liver tissue 3D bioprinting. Further studies for the incorporation of biliary networks in the bioartificial livers have been emphasized. It is expected that when all the bottle-neck problems for liver 3D bioprinting are solved, batch (i.e. mass) and personalized production of bioartificial livers will make it very easy to treat end-stage liver diseases.
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Cite this article as:
Three-dimensional Printing-Driving Liver Therapies, Current Medicinal Chemistry 2021; 28 (33) . https://dx.doi.org/10.2174/0929867328666210419124246
DOI https://dx.doi.org/10.2174/0929867328666210419124246 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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