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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Meta-Analysis

体重减轻和痴呆风险：队列研究的荟萃分析

卷 18, 期 2, 2021

发表于: 14 April, 2021

页: [125 - 135] 页: 11

弟呕挨: 10.2174/1567205018666210414112723

价格: $65

摘要

背景：体重减轻是老年人的普遍现象，被确定为健康状况的重要指标。许多流行病学研究调查了体重减轻与痴呆之间的关联，但结果并不一致。 目的：检查和确定体重减轻与痴呆风险之间的关联。 方法：从 PubMed、Embase 和 Ovid 数据库中搜索到 2018 年 10 月的涉及体重减轻和痴呆症的符合条件的队列研究。使用汇总相对风险 (RR) 及其 95% 置信区间 (CI) 来估计体重减轻对体重减轻的影响。痴呆症的风险。进行亚组分析和敏感性分析以探索异质性的潜在来源。 Begg 检验和 Egger 检验用于评估发表偏倚。 结果：本荟萃分析共纳入了 20 项队列研究，共有 38,141 名参与者。体重减轻与痴呆风险显着相关（RR=1.26，95% CI=1.15-1.38）。 BMI 下降≥0.8 个单位（RR=1.31，95% CI=1.10-1.56）和≥4%（RR=1.19，95% CI=1.03-1.38）可能会增加痴呆的风险。体重减轻的人患全因痴呆的风险增加了 31% (RR=1.31, 95% CI=1.15-1.49)，阿尔茨海默病的发生风险增加了 25% (RR=1.25, 95% CI=1.07-1.46) ）。体重正常的参与者体重减轻与超重个体（RR=1.22，95% CI=1.11-1.34）具有相似的痴呆风险（RR=1.21，95% CI=1.06-1.38）。 结论：体重减轻可能与痴呆风险增加有关，尤其是阿尔茨海默病。保持体重稳定可能有助于预防痴呆症。

关键词: 减肥、痴呆、队列研究、荟萃分析、肥胖、预防。

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