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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Terretonins from Aspergillus Genus: Structures, Biosynthesis, Bioactivities, and Structural Elucidation

Author(s): Sabrin R.M. Ibrahim*, Gamal A. Mohamed, Hani M.K. Kamal, Shaimaa G.A. Mohamed and Amgad I.M. Khedr

Volume 19, Issue 2, 2022

Published on: 12 April, 2021

Page: [257 - 269] Pages: 13

DOI: 10.2174/1570193X18666210412162654

Price: $65

Abstract

Fungi are considered a prosperous pool of microbial bio-metabolites. Terretonins are meroterpenoids that are reported mainly from the Aspergillus genus. They exhibit unique tetracyclic core skeletons and various bioactivities. The current review summarizes the published researches on the source, biosynthesis, isolation, structural characterization, and bioactivities of terretonins that have been reported from Aspergillus species, as well as from synthetic sources. A literature search on the published studies was conducted over different databases, including Web of Science, MedLine (PubMed), Scopus, SpringerLink, Google Scholar, SciFinder, Wiley, and ACS Publications up to 2020. In this work, 18 compounds from Aspergillus species and synthetic sources are depicted. They have unrivaled and diversified skeletons as well as various bioactivities. Moreover, 37 references are included. Terretonins form a class of fungal bio-metabolites that attain all the characters for becoming lead compounds in their particular therapeutic category.

Keywords: Fungi, Aspergillus, terretonins, meroterpenoids, biosynthesis, biological activities.

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