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Review Article

血红蛋白囊泡作为输血替代方案的转化研究

卷 29, 期 3, 2022

发表于: 12 April, 2021

页: [591 - 606] 页: 16

弟呕挨: 10.2174/0929867328666210412130035

价格: $65

摘要

临床情况是输血的血液变得稀缺或无法获得。由于献血和输血系统造成的各种困难，对输血替代办法的大量需求依然存在。血红蛋白囊泡（Hb-V）是人工氧载体，正在开发用作输血替代品。就像红细胞（RBC）的生物膜一样，用于Hb封装的磷脂囊泡（脂质体）可以保护人体免受分子Hb的毒性作用。主要的HbV成分Hb是从丢弃的人类捐献的血液中获得的。因此，HbV可归类为靶向外周组织氧气的生物制剂。纯化程序严格消除了病毒污染的可能性。它还可以去除红细胞中存在的所有伴随的不稳定酶，以最大限度地提高感染安全性。脱氧的HbV可在环境温度下储存多年，可作为输血的替代方法，用于从出血性休克和O2治疗中复苏。此外，最近的一项研究阐明了一氧化碳（CO）结合的HbV对抗氧化和抗炎的有益作用.静脉内给药后，HbV（HbO2→metHb + O2 -.）的自氧化是不可避免的。亚甲蓝共注射可有效提取红细胞内糖酵解电子能，降低甲基氢氧化酶。其他吩噻嗪染料也可以作为电子介质，以提高HbV的功能寿命。本文综述了HbV针对临床应用的研究和开发的最新进展。

关键词: 人造血液，血液替代品，一氧化碳，电子介质，糖酵解电子能，血红蛋白基氧载体，脂质体，NAD（P）H。

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