摘要
目的:本综述旨在研究与 COVID-19 感染最相关的受体家族和功能,并提出大多数 COVID-19 受体主要表达的组织和细胞位置。 方法:本系统评价是根据 PRISMA 指南进行的。使用了 PubMed、Cochrane、SciELO、Lilacs、Web of Science 和 DOAJ 数据库。本综述纳入了研究 COVID-19 相关受体的临床试验和研究文章。采用R编程语言编制图表和受体网络,采用SPSS(26v)软件进行统计分析(PROSPERO:CRD42020210643)。 结果:大多数关于受体参与 COVID-19 的研究包括血浆受体和 G 蛋白偶联受体家族(p<0.05)。这些受体在大脑中高度表达(24%),其中 80% 可以在蛋白质网络中相互作用,对各种组织发挥一定的调节作用。在参与 COVID-19 的受体网络中,主要有影响的受体是 EGFR,大多数受体与疾病的病理过程有关(p<0.05),包括 COVID-19 中炎症反应的放大,这可能在某些情况下与神经系统疾病有关。对参与 COVID-19 的受体的研究主要包括来自美国、西班牙和巴西的患者(p<0.05)。 结论:血浆受体和 G 蛋白偶联受体,尤其是 EGFR,参与 COVID-19 脑炎症过程的病理作用,在本综述中显示出重要意义。
关键词: 脑、COVID-19、表皮生长因子受体、G 蛋白偶联受体、炎症、血浆受体。
Current Medicinal Chemistry
Title:The Main Receptors Involved in the COVID-19: A Systematic Review and Meta-Analysis
Volume: 28 Issue: 34
关键词: 脑、COVID-19、表皮生长因子受体、G 蛋白偶联受体、炎症、血浆受体。
摘要:
Objective: This review aims to study the receptor's family and functions most related to COVID-19 infection and also suggest the tissue and cell location on which the majority of COVID-19 receptors are mainly expressed.
Methods: This systematic review is according to PRISMA guidelines. PubMed, Cochrane, SciELO, Lilacs, Web of Science, and DOAJ databases were used. Clinical trials and research articles studying receptors related to COVID-19 were included in this review. R programming language was used to elaborate charts and receptors network, and SPSS(26v) software was used to perform statistical analysis (PROSPERO: CRD42020210643).
Results: The majority of studies on the involvement of receptors in COVID-19 included plasma receptors and G protein-coupled receptor families (p<0.05). These receptors are highly expressed in the brain (24%) and 80% of them can interact with each other in a protein network, exerting some regulatory effects on various tissues. The main influential receptor in the network of receptors involved in the COVID-19 was the EGFR and the majority of receptors were associated with pathological processes of the disease (p<0.05), including the amplification of inflammatory responses in COVID-19, which may be related to neurological disorders in some cases. Studies on receptors involved in the COVID-19 included mainly patients from the United States, Spain, and Brazil (p<0.05).
Conclusion: Plasma receptors and G protein-coupled receptors, especially the EGFR, involved in pathological effects of the COVID-19 inflammatory process in the brain have shown significant importance in this review.
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Cite this article as:
The Main Receptors Involved in the COVID-19: A Systematic Review and Meta-Analysis, Current Medicinal Chemistry 2021; 28 (34) . https://dx.doi.org/10.2174/0929867328666210405113253
DOI https://dx.doi.org/10.2174/0929867328666210405113253 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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