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Mini-Review Article

结直肠癌临床前药物发现：天然化合物的焦点

卷 22, 期 9, 2021

发表于: 05 April, 2021

页: [977 - 997] 页: 21

弟呕挨: 10.2174/1389450122666210405105206

价格: $65

摘要

背景：结直肠癌（CRC）被认为是全球最主要和最致命的癌症之一。目前，这种癌症的主要临床管理包括化疗和手术；然而，这些治疗会导致耐药性和严重的副作用，因此发现一种替代的和潜在的治疗结直肠癌的方法是至关重要的。许多治疗性癌症最初是从传统医学中使用的天然代谢物中识别出来的，最近几类研究表明，许多天然产物具有抗结直肠癌的潜在作用，并且可以辅助化疗治疗结直肠癌的作用。已经表明，大多数患者对天然化合物耐受性良好，即使在高剂量下也没有任何毒性迹象。常规化疗药物与天然药物化合物的相互作用在癌症探索和治疗中呈现出新的特征。大多数天然化合物通过诱导结直肠癌细胞凋亡和阻止细胞周期(特别是在G、S和G2/M期)来抑制恶性细胞增殖，从而抑制肿瘤生长。 目的：本文旨在综述天然化合物(生物碱、黄酮类、多糖、多酚、萜类、内酯、醌类等)——在体外对结直肠癌细胞系和/或在动物模型的体内实验中被鉴定具有抗结直肠癌活性。 结论：大多数研究的活性天然化合物通过不同的机制和途径在体内外具有抗结直肠癌活性，可作为临床医生支持癌症患者化疗治疗策略和治疗剂量的辅助手段。

关键词: 天然化合物，药物发现，生物标记，结直肠癌，小型综述，化疗。

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