摘要
肺癌是全球癌症死亡的主要原因。由于耐药性的发展、对治疗的反应、药物-药物相互作用或抗癌药物的非特异性靶向,肺癌治疗的管理通常是无效的。天然化合物在肺癌中显示出前景和潜在活性,副作用非常少。同时,抗癌药物与天然化合物的组合作用提供了协同作用,有助于增强对癌细胞的整体治疗作用。在癌症中,细胞凋亡的失调促进癌细胞存活,导致癌症进展。许多抗癌药物会引起调节癌症的基因突变,应该杀死癌细胞,但会导致化学抗性。有许多天然化合物可以特异性靶向与癌症进展相关的不同细胞信号通路,从而在靶细胞中提供细胞毒性作用。这些化合物的重要性正在出现在许多具有双重作用的疗法中,通常包括天然化合物。在这篇综述中,我们介绍了这些天然化合物的选择以及它们如何靶向肺癌细胞,重点关注细胞信号通路。需要进一步的工作来描述天然化合物在治疗癌症中的潜在作用。
关键词: 肺癌,天然化合物,细胞凋亡,治疗,药物-药物相互作用,细胞信号通路。
Current Medicinal Chemistry
Title:Therapeutic Potential of Natural Compounds in Lung Cancer
Volume: 28 Issue: 39
关键词: 肺癌,天然化合物,细胞凋亡,治疗,药物-药物相互作用,细胞信号通路。
摘要: Lung cancer is a leading cause of cancer deaths worldwide. The management of lung cancer treatment is often ineffective as a result of the development of drug resistance, reactions to treatment, drug-drug interactions or non-specific targeting of the anticancer drugs. Natural compounds show promise and potential activity in lung cancer with very few side effects. While, the combinatorial action of an anti-cancer drug with a natural compound provides synergistic action which helps boost the overall therapeutic action against cancer cells. In cancer, there is a dysregulation of apoptosis which facilitates the cancer cell to survive, resulting in progression of cancer. Many cancer drugs cause mutations of genes that regulate cancer and should kill the cancer cell but lead to chemoresistance. There are many natural compounds that could specifically target different cell signalling pathways associated with cancer progression to provide a cytotoxic effect in the target cell. The importance of these compounds is emerging in many therapies developed with dual action often including a natural compound. In this review, we present a selection of these natural compounds and how they target lung cancer cells with a focus on the cell signalling pathways. Further work is required to delineate the potential action of natural compounds in the treatment against cancer.
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Cite this article as:
Therapeutic Potential of Natural Compounds in Lung Cancer, Current Medicinal Chemistry 2021; 28 (39) . https://dx.doi.org/10.2174/0929867328666210322103906
DOI https://dx.doi.org/10.2174/0929867328666210322103906 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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