摘要
骨质疏松症在中老年人群中很常见,其主要特征是骨量减少、骨微结构改变,并相应增加骨折风险的疾病。这是一种受多种因素影响的疾病,在绝经后的妇女中更为常见。目前,骨质疏松症的治疗主要是防止骨吸收,降低骨折风险;多种药物已用于骨质疏松症的治疗,并取得了良好的效果。近年来,随着对肠道微生物研究的深入,有报道称肠道菌群对骨代谢在免疫方面有较强的影响。在小鼠模型中可以观察到,肠道菌群可能是改变骨密度的新靶点。因此,肠道菌群是一个影响和调节钙和维生素D吸收的复杂系统。它通过自身分泌相关影响因子和自身活动来影响肠道的通透性,进而影响人体激素的分泌和免疫反应。辅助性T细胞、淋巴细胞、TNF、IL-17和RANKL系统起关键作用。由于缺乏研究数据,益生菌和益生元对人类的影响是有争议的。然而,许多研究表明,益生菌在不同动物中的作用因性别、年龄和激素分泌而不同。肠道菌群的变化与骨质减少和/或骨质疏松密切相关。改变其成分和活性可能是改变骨质量的可靠策略,但是还需要进一步的临床研究。
关键词: 益生菌,益生元,骨质疏松症,骨密度,RANKL,免疫系统。
Current Medicinal Chemistry
Title:The Role of Probiotics and Prebiotics in Osteolastogenesis and Immune Relevance
Volume: 28 Issue: 25
关键词: 益生菌,益生元,骨质疏松症,骨密度,RANKL,免疫系统。
摘要: Osteoporosis is very common in middle-aged and elderly people, and its main feature is a disease characterized by bone mass reduction and bone microstructure changes, accompanied by a corresponding increase in the risk of fracture. This is a disease affected by many factors and is more common in postmenopausal women. Currently, the treatment of osteoporosis is mainly to prevent bone resorption and reduce the risk of fracture; a variety of drugs have been used in the treatment of osteoporosis and achieved good results. In recent years, with the in-depth study of intestinal microorganisms, a strong impact of intestinal microflora on bone metabolism in terms of immunity has been reported. It can be observed in mouse-based models, which indicates that intestinal flora may be a potential new target for changing bone mineral density (BMD). Therefore, the intestinal flora is a complex system that affects and regulates the absorption of calcium and vitamin D. It affects the permeability of the intestine through its own secretion of related influencing factors and its own activities, and further affects the secretion of human hormones and immune response. Besides that, T helper cells, lymphocytes, TNF, IL-17, and the RANKL system play a key role. The impact of probiotics and prebiotics on humans is controversial due to the scarcity of research data. However, many studies have shown that the role of probiotics in different animals varies with gender, age and hormone secretion. Changes in the intestinal flora are closely related to osteopenia and/or osteoporosis. Changing its composition and activity may be a reliable strategy for altering bone quality, although further clinical studies are needed to determine the correct human method.
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Cite this article as:
The Role of Probiotics and Prebiotics in Osteolastogenesis and Immune Relevance, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666210316115126
DOI https://dx.doi.org/10.2174/0929867328666210316115126 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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