Abstract
Contact hypersensitivity (CHS) is an antigen-specific response elicited by exposure to certain low-molecularweight compounds termed haptens, and is the disease often seen clinically. CHS has also been used as a useful model to assess antigen-specific and T cell-dependent immune response. A wide variety of cells are thought to be involved in the pathogenesis of CHS. Keratinocytes and T cells are regarded as important factors, and besides these cells, mast cells, fibroblasts, B cells, macrophages, neutrophils have been demonstrated to be involved. From the studies of gene knockout experiments, it has been gleaned that IL-1β, IL-2, IL-3, IL-4, IL-6, IL-10, IFN-γ, TNF-α are associated with elicitation of CHS. While the roles of these cytokines in CHS have been well elucidated, recent attention has been directed at members of the superfamily of chemoattractant cytokines that are collectively termed chemokines. Both of mouse and human CHS studies showed chemokine genes were sequentially expressed in the elicitation site, suggesting that chemokine-mediated nonimmunological mechanisms precede and corroborate antigen-specific mechanisms during elicitation of CHS. In a mouse CHS study, topical treatment with a corticosteroid drug suppressed completely the infiltrates as well as the ear swelling response. In addition, the up-regulation of gene expressions for chemokines was suppressed by the corticosteroid drug, indicating that the expression of chemokine genes seems to be essential for orientating non-specific skin response to hapten-specific CHS response through the recruitment of inflammatory cells from the circulation into the tissue site. In this review, we discuss the proposed function of chemokines in the pathogenesis of CHS.
Keywords: Chemokine, contact hypersensitivity, corticosteroid
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Chemokines and Their Receptors as a Target for the Treatment of Contact Hypersensitivity
Volume: 7 Issue: 1
Author(s): Yoshimi Niwano, Gaku Mitsui and Masahiro Kohno
Affiliation:
Keywords: Chemokine, contact hypersensitivity, corticosteroid
Abstract: Contact hypersensitivity (CHS) is an antigen-specific response elicited by exposure to certain low-molecularweight compounds termed haptens, and is the disease often seen clinically. CHS has also been used as a useful model to assess antigen-specific and T cell-dependent immune response. A wide variety of cells are thought to be involved in the pathogenesis of CHS. Keratinocytes and T cells are regarded as important factors, and besides these cells, mast cells, fibroblasts, B cells, macrophages, neutrophils have been demonstrated to be involved. From the studies of gene knockout experiments, it has been gleaned that IL-1β, IL-2, IL-3, IL-4, IL-6, IL-10, IFN-γ, TNF-α are associated with elicitation of CHS. While the roles of these cytokines in CHS have been well elucidated, recent attention has been directed at members of the superfamily of chemoattractant cytokines that are collectively termed chemokines. Both of mouse and human CHS studies showed chemokine genes were sequentially expressed in the elicitation site, suggesting that chemokine-mediated nonimmunological mechanisms precede and corroborate antigen-specific mechanisms during elicitation of CHS. In a mouse CHS study, topical treatment with a corticosteroid drug suppressed completely the infiltrates as well as the ear swelling response. In addition, the up-regulation of gene expressions for chemokines was suppressed by the corticosteroid drug, indicating that the expression of chemokine genes seems to be essential for orientating non-specific skin response to hapten-specific CHS response through the recruitment of inflammatory cells from the circulation into the tissue site. In this review, we discuss the proposed function of chemokines in the pathogenesis of CHS.
Export Options
About this article
Cite this article as:
Niwano Yoshimi, Mitsui Gaku and Kohno Masahiro, Chemokines and Their Receptors as a Target for the Treatment of Contact Hypersensitivity, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (1) . https://dx.doi.org/10.2174/187152308783769159
DOI https://dx.doi.org/10.2174/187152308783769159 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture
Current Drug Metabolism Pivotal Pathogenic and Biomarker Role of Chlamydia Pneumoniae in Neurovascular Diseases
Current Neurovascular Research Identifying the Cellular Targets of Bioactive Small Molecules with Activity-Based Probes
Current Medicinal Chemistry The Role of Probiotics and Prebiotics in Osteolastogenesis and Immune Relevance
Current Medicinal Chemistry Mangiferin – a Bioactive Xanthonoid, not only from Mango and not just Antioxidant
Mini-Reviews in Medicinal Chemistry Targeting Protein Kinase C (PKC) in Physiology and Cancer of the Gastric Cell System
Current Medicinal Chemistry Signaling Through Rho GTPase Pathway as Viable Drug Target
Current Medicinal Chemistry Bicyclol: A Novel Drug for Treating Chronic Viral Hepatitis B and C
Medicinal Chemistry Physiological Significance and Therapeutic Potential of Adrenomedullin in Pulmonary Hypertension
Cardiovascular & Hematological Disorders-Drug Targets TNF-Related Apoptosis-Inducing Ligand (TRAIL) as a Pro-Apoptotic Signal Transducer with Cancer Therapeutic Potential
Current Pharmaceutical Design Design and Development of Novel 2-(Morpholinyl)-N-substituted Phenylquinazolin-4-amines as Selective COX-II Inhibitor
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Decorin Biology, Expression, Function and Therapy in the Cornea
Current Molecular Medicine The Role of Negative Costimulators During Parasitic Infections
Endocrine, Metabolic & Immune Disorders - Drug Targets The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects
Current Cardiology Reviews Alcohol and the Cardiovascular System: A Double-Edged Sword
Current Pharmaceutical Design The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target
Current Neuropharmacology Microfluidic Methods for Non-Viral Gene Delivery
Current Gene Therapy Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment
Current Drug Targets Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus
Current Medicinal Chemistry Acridones As Antiviral Agents: Synthesis, Chemical and Biological Properties
Current Medicinal Chemistry