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Review Article

结直肠癌早期检测的研究进展：非侵入性生物标志物

卷 22, 期 9, 2021

发表于: 03 March, 2021

页: [1043 - 1053] 页: 11

弟呕挨: 10.2174/1389450122666210303100048

价格: $65

摘要

背景：结直肠癌是世界上第三大常见诊断癌症。目前，结肠镜检查仍然是结直肠癌检测的金标准诊断测试。尽管如此，这项技术是侵入性的和昂贵的。引人注目的现行战略侧重于开发负担得起的早期诊断结直肠癌的方法。采用生物标志物分析引入合适的非侵入性、敏感性和特异性诊断试验用于早期结直肠癌检测似乎是减少不必要结肠镜检查数量的基本需要。在这篇综述中，我们提供了一个单一和多组生物标记物(基因组标记物、转录组标记物、蛋白质组标记物、炎症标记物和微生物组标记物)的概述，包括血液和粪便中用于早期结直肠癌检测的无创检测。 方法：利用PubMed/Medline、科学网和循证医学数据库进行文献检索，查找过去6年发表的相关研究。本综述包括43项相关研究。结果:主要结果强调了在血液或粪便中研究的单一诊断生物标志物的敏感性和特异性。次要结果揭示了血液或粪便中生物标志物组(组合)的敏感性和特异性。虽然有些标记显示出更好的性能，但其他标记不适合筛选目的。 结论：有必要调整可能干扰可靠结果的实验和分析测试，以替代或补充目前使用的标记物。然而，成功的无创性检查需要大量临床队列的可靠验证和确认，才能发挥结肠镜检查的作用。

关键词: 结直肠癌，结肠镜检查，无创性，标志物，敏感性，特异性，早期检测。

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