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Systematic Review Article

纳米颗粒在胶质母细胞瘤细胞凋亡基因治疗中的作用:系统综述

卷 21, 期 3, 2021

发表于: 24 February, 2021

页: [230 - 245] 页: 16

弟呕挨: 10.2174/1566523221666210224110454

价格: $65

摘要

背景：多形性胶质母细胞瘤(GBM)是最常见和致命的胶质瘤类型。纳米粒子(NPs)被用于基因治疗GBM的新途径。 介绍：本文就NPs作为靶向载体在GBM细胞凋亡基因治疗中的作用作一综述。本文就NPs作为靶向载体在GBM细胞凋亡基因治疗中的作用作一综述。 方法：使用PubMed、ISI Web of Science、Scopus检索截至2020年9月4日的相关文献，不受语言限制，检索关键词为nanoparticle、glioblastoma、gene therapy、apoptosis等相关词。本文以PRISMA方案为基础，综述了纳米颗粒、各种基因治疗要素载体对GBM细胞体外和体内凋亡的影响。选择的文章被考虑使用特定的分数对文章的质量。数据提取和质量评价由两位审稿人完成。 结果：在101篇检索到的文章中，有42篇符合纳入标准，因此，其他59篇最终被排除。在GBM基因治疗研究中使用最广泛的NP是聚酰胺胺(PAMAM)。对GBM中细胞凋亡最常见的基因治疗方法是使用siRNA。 结论：综上所述，这些研究证实了NPs是一种提高基因治疗GBM细胞凋亡效率和特异性的实际选择。但NP型的选择和基因治疗机制影响GBM细胞的凋亡效率。

关键词: 纳米粒子，基因治疗，胶质母细胞瘤，凋亡，PRISMA，聚胺胺

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