Synthesis of 4-Aryldihydrocoumarins via a Sequential Michael Addition- Lactonization Route

Title:Synthesis of 4-Aryldihydrocoumarins via a Sequential Michael Addition- Lactonization Route

Volume: 8 Issue: 3

Author(s): Anshu K. Sinha, Chandra M. Srivastava, Gyandshwar K. Rao, Manvika Karnatak, Ved P. Verma*Varun Rawat*

Affiliation:

• Department of Chemistry, Banasthali Vidyapith, Banasthali Newai-304022, Rajasthan,India

• Amity School of Applied Sciences, Amity University Haryana, Gurugram-122413,India

Keywords: Organocatalysis, calixarene, sequential reactions, coumarins, michael addition, lactonization.

Abstract:

Background: Coumarin and its derivatives have attracted the attention of synthetic chemists due to their importance in pharmaceutical and medicinal chemistry. The acid-catalyzed cyclization route constitutes the method of choice to access these important compounds.

Objective: In this paper, we have discussed the synthesis of 4-aryldihydrocoumarins via a one-pot p-sulfonic acid calix[4]arene catalyzed reaction.

Methods: The easily prepared calix[4]arene derivative catalyzes a sequential reaction involving Michael addition followed by intramolecular lactonization to afford the title compound in effective yield.

Results: The described methodology is devoid of any metal salt, thus making it a very appealing protocol to safely produce dihydrocoumarins of pharmacological importance.

Conclusion: The easy recovery, non-toxicity, and reusability of the catalytic system are some of the other advantages of our procedure. In addition, the catalyst efficiency is not compromised after its successive use in reactions.

Cite this article as:

Sinha K. Anshu , Srivastava M. Chandra , Rao K. Gyandshwar , Karnatak Manvika , Verma P. Ved *, Rawat Varun *, Synthesis of 4-Aryldihydrocoumarins via a Sequential Michael Addition- Lactonization Route, Current Organocatalysis 2021; 8 (3) . https://dx.doi.org/10.2174/2213337208666210223151108