基于ICP-MS的中空纤维流场流分馏后去垢纳米颗粒回收方法

Title:ICP-MS-based Approach to Determine Nanoparticle Recovery After Hollow Fiber Flow Field Flow Fractionation

Volume: 29 Issue: 2

关键词: 表征，特别是中空纤维流场流分馏 （HF5），连字， 电感 耦合等离子体质谱（ICP-MS），纳米颗粒，激光烧蚀ICP-MS（LA-ICP-MS）。

摘要: Compared to the classical chemicals, nanoparticles (NPs) exhibit unique properties, which lead to challenges in sample preparation and analysis. Fractionation techniques and, in particular, hollow fiber flow field flow fractionation (HF5) have recently become popular in the characterization and quantification of nanomaterials, because of their fine fractionation capability in the nanoscale-range. When dealing with NPs, a great drawback during fractionation is the loss of particles in the fractionation devices, tubing and connectors. There is a need for studies to systematically explore and assess the quality of the fractionation process. A combination of two complementary mass-based setups was used to determine particle loss in HF5. Inductively coupled plasma mass spectrometry (ICP-MS) enabled the estimation of recovery rates for NPs after HF5 separation. Reciprocally, laser ablation ICP-MS (LA-ICP-MS) permitted the evaluation of particles retained on the hollow fiber. 15 nm Au-NPs in different concentrations were evaluated in this study and showed a recovery level for Au-NPs of 50 – 65% based on the applied concentrations after a complete HF5 separation run. Detection of sample deposition on the hollow fiber by LA-ICP-MS indicated a sample loss of about 8%. These findings are important for experiments relying on fractionation of low concentrated nanoparticulate samples.

Cite this article as:

ICP-MS-based Approach to Determine Nanoparticle Recovery After Hollow Fiber Flow Field Flow Fractionation, Current Medicinal Chemistry 2022; 29 (2) . https://dx.doi.org/10.2174/0929867328666210222094913