摘要
包膜病毒属于一大类导致多种严重疾病的病原体。它们传播到新的领土是人类历史上重大流行病的原因,包括 1918 年的西班牙流感和最新的 COVID-19 大流行。由于它们的外膜主要由宿主脂质组成,包膜病毒对酶的抵抗力更强,并且比裸体病毒更不易受到宿主免疫防御的影响。因此,开发对抗包膜病毒感染的有效方法是本世纪抗病毒治疗的重大挑战。本综述重点介绍包膜病毒的特征、它们在进入阶段的重要性、靶向包膜膜介导进入的药物以及专门设计用于靶向包膜的药物。这些化合物的广谱抗病毒活性可归因于它们影响包膜的能力,包膜是几种病毒共有的基本结构特征。当没有特定的药物或疫苗可用于阻断病毒感染时,这使得此类化合物制剂引起极大兴趣。
关键词: 包膜、进入、广谱抗病毒剂、病毒、脂质、膜、新兴病毒。
Current Medicinal Chemistry
Title:Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target
Volume: 28 Issue: 34
关键词: 包膜、进入、广谱抗病毒剂、病毒、脂质、膜、新兴病毒。
摘要: Enveloped viruses belong to a large class of pathogens responsible for multiple serious diseases. Their spread into new territories has been the cause of major epidemics throughout human history, including the Spanish flu in 1918 and the latest COVID-19 pandemic. Thanks to their outer membrane, consisting essentially of host lipids, enveloped viruses are more resistant to enzymes and are also less susceptible to host immune defenses than their naked counterparts. Therefore, the development of effective approaches to combat enveloped virus infections represents a major challenge for antiviral therapy in the current century. This review focuses on the characteristics of enveloped viruses, their importance in the entry phase, drugs targeting envelope membrane- mediated entry, and those specifically designed to target the envelope. The broad- -spectrum antiviral activity of these compounds can be attributed to their ability to affect the envelope, an essential structural feature common to several viruses. This makes this class of compounds agents of great interest when no specific drugs or vaccines are available to block viral infections.
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Cite this article as:
Viral Envelope Membrane: A Special Entry Pathway and a Promising Drug Target, Current Medicinal Chemistry 2021; 28 (34) . https://dx.doi.org/10.2174/0929867328666210218182203
DOI https://dx.doi.org/10.2174/0929867328666210218182203 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

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