摘要
背景:轻度认知障碍(MCI)代表正常衰老和痴呆症之间的中间和可修正阶段。迫切需要通过血液生物标记物对MCI进行简单,无创的检测。 目的:本研究旨在回顾性评估红细胞(RBC)指数与MCI的关联,并选择最佳的血液学特征以检测中国老年人的MCI。 方法:采用配对病例对照研究,对85对MCI受试者和健康对照进行了研究。匹配的标准是年龄,性别和受教育程度。分析了所有样品的RBC指数,包括血红蛋白(HGB),血细胞比容(HCT),平均红细胞体积(MCV),平均红细胞血红蛋白浓度(MCHC)和红细胞分布宽度标准偏差(RDW-SD)。使用条件逻辑回归模型评估RBC指数与MCI之间的关联。生物标志物的诊断功效通过接受者操作特征(ROC)进行评估。 结果:在所有RBC指标中,两组之间的HGB(124.82±7.89与133.93±4.52,P <0.001)和RDW-SD(45.29±2.03与41.34±4.41,P <0.001)有显着差异。在逻辑回归模型中,在对生活方式因素和合并症进行调整后,发现较高的HGB和较低的MCI风险之间存在显着的统计学联系(校正后的OR:0.831; 95%CI:0.773-0.893),较高的RDW-SD和较高的发生MCI的风险(调整后的OR:1.575; 95%CI:1.326-1.872)。 ROC分析表明,结合HGB和RDW-SD(AUC = 0.842)发现ROC曲线(AUC)下的最大面积,其次是HGB(AUC = 0.795),最后是适度的RDW-SD(AUC = 0.777)。 HGB <131 g / L和RDW-SD> 43.4 fL的组合产生的敏感性为92%,特异性为89%,其总体诊断效率优于单独的HBG和RDW-SD。 结论:单独发现较低的HGB和较高的RDW-SD会明显增加MCI的风险,并提供适度的敏感性和特异性作为诊断指标。 HGB和RDW-SD的组合更敏感,并且具有更高的分类准确性,可将MCI与健康对照区分开。需要进一步的前瞻性研究来阐明HGB与RDW-SD组合是否可能是AD早期诊断的潜在诊断工具。
关键词: 轻度认知障碍,老年人,生物标志物,ROC曲线,匹配的病例对照研究,痴呆。
Current Alzheimer Research
Title:Association of Red Blood Cell Indices with Mild Cognitive Impairment in Chinese Elderly Individuals: A Matched Case-control Study
Volume: 17 Issue: 13
关键词: 轻度认知障碍,老年人,生物标志物,ROC曲线,匹配的病例对照研究,痴呆。
摘要:
Background: Mild cognitive impairment (MCI) represents an intermediate and modifiable stage between normal aging and dementia. There is an urgent need for simple, non-invasive testing of MCI by blood biomarkers.
Objective: This study aimed to retrospectively evaluate the association of red blood cell (RBC) indices with MCI, and select the best hematologic characteristic for detection of MCI in elderly Chinese.
Methods: Matched case-control study was carried out with 85 pairs of MCI subjects and healthy controls. The matching criteria was age, gender and education attainment. All samples were analyzed for RBC indices, including hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width-standard deviation (RDW-SD). A conditional logistic regression model was used to evaluate the association between RBC indices and MCI. The diagnostic efficacy of the biomarkers was evaluated by receiver operating characteristics (ROC).
Results: Among all RBC indices, there were significant differences in HGB (124.82 ± 7.89 vs. 133.93 ± 4.52, P < 0.001) and RDW-SD (45.29 ± 2.03 vs. 41.34 ± 4.41, P < 0.001) between two groups. In the logistic regression model, after adjustment for lifestyle factors and comorbidities, significant statistically associations have been found between higher HGB and lower risk of MCI (adjusted OR: 0.831; 95% CI: 0.773-0.893), higher RDW-SD and a higher risk of MCI (adjusted OR: 1.575; 95% CI: 1.326- 1.872). ROC analysis suggested that the largest area under the ROC curve (AUC) was found with the combination of HGB and RDW-SD (AUC = 0.842), followed by HGB(AUC = 0.795), and finally by modest RDW-SD (AUC = 0.777). Combination of HGB <131 g/L and RDW-SD >43.4 fL yielded a sensitivity of 92% and a specificity of 89%, overall diagnosis efficiency of which were better than HBG and RDW-SD alone.
Conclusion: Lower HGB and higher RDW-SD alone were significantly found to be associated with increased risk of MCI, and offered modest sensitivity and specificity as a diagnostic marker. The combination of HGB and RDW-SD was more sensitive and had higher classification accuracy for differentiating MCI from healthy controls. Further prospective research is needed to clarify whether HGB in combination with RDW-SD may be a potential diagnostic tool for early diagnosis of AD.
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Association of Red Blood Cell Indices with Mild Cognitive Impairment in Chinese Elderly Individuals: A Matched Case-control Study, Current Alzheimer Research 2020; 17 (13) . https://dx.doi.org/10.2174/1567205018666210218144856
DOI https://dx.doi.org/10.2174/1567205018666210218144856 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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