Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

Title:Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

Volume: 21 Issue: 15

Author(s): Xiliang Yang*, Jinping Liu, Jiahui Mei , Rui Jiang, Shizheng Tu, Huafeng Deng, Jing Liu, Sumei Yang and Juan Li*

Affiliation:

• Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430081,China

• Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China

Keywords: Penicillium, secondary metabolite, marine fungus, antimicrobial, cytotoxicity, enzymatic activity.

Abstract: In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine- derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

Cite this article as:

Yang Xiliang *, Liu Jinping , Mei Jiahui , Jiang Rui , Tu Shizheng, Deng Huafeng, Liu Jing , Yang Sumei and Li Juan *, Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi, Mini-Reviews in Medicinal Chemistry 2021; 21 (15) . https://dx.doi.org/10.2174/1389557521666210217093517