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Review Article

间充质干细胞衍生的细胞外囊泡的再生潜力

卷 22, 期 2, 2022

发表于: 11 February, 2021

页: [98 - 119] 页: 22

弟呕挨: 10.2174/1566524021666210211114453

价格: $65

摘要

间充质干细胞（MSCs）是多能细胞，可以分化成不同的细胞谱系。基于MSC的治疗已成为再生医学中广泛实验的治疗策略，具有可观的结果。最近的报告表明，MSCs的大部分治疗效果是由其通过细胞外囊泡（EV）表达的分泌组介导的。EV是脂质双层结合的组分，携带细胞蛋白，mRNA，lncRNA和其他分子，以介导细胞间通讯和信号传导。事实上，已经观察到MSC衍生的EV具有与MSCs相同的治疗效果，并且不良反应最小，并且可以用作基于MSC的治疗的替代治疗方法。使用各种动物模型已经观察到MSC-EV的再生活性与多个细胞/组织谱系有关。然而，进一步的研究和临床试验对于推进这种新型治疗策略至关重要。本综述提供了对MSC-EV在血管生成，神经发生，肝肾再生以及伤口愈合方面的应用的现有文献的见解。

关键词: 细胞外囊泡，间充质干细胞，再生医学，分泌组，旁分泌信号传导，再生。

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