摘要
由大多数细胞释放的细胞外囊泡(EV)通过在各种囊泡(即外泌体,凋亡体,蛋白质复合物,高密度脂质(HDL)微囊泡等)中运输DNA,RNA和蛋白质,构成了细胞 - 细胞通讯的新系统。为了确保体细胞活性的准确调节,EV作为独立的代谢单元,介导多种疾病(如心血管疾病,代谢疾病,神经退行性疾病,免疫性疾病和癌症)的代谢稳态和病理生理学。Whist检查了EV生物分子货物及其微环境,导致组织再生中细胞的表观遗传改变,研究进一步了解了EV的生物发生及其在细胞生物学和致病性中的潜在作用。由于其体积小,无毒力,灵活性和跨越生物屏障的能力,EVs在各种疾病中具有有希望的治疗潜力。本文描述了EV在细胞间通讯和生物信息传递中的作用机制,以及EVin诱导的受体细胞表观遗传变化在组织再生过程中引起表型改变的一些细节。我们还强调了EVs在器官特异性再生中的一些治疗潜力。
关键词: 细胞通讯,细胞信号传导,细胞治疗,表观遗传学,外泌体,细胞外囊泡,微囊泡,再生医学。
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