摘要
冠状病毒(cov)属于人畜共患超衣壳病毒的一个大家族,包括约40种含有rna的病毒,其中一些毒株能够对肺部和呼吸道造成损害。严重急性呼吸系统综合征冠状病毒(SARS- cov)是导致2003年全球爆发SARS的罪魁祸首。2019-2020年,SARS-CoV-2在全球的快速传播造成了重大健康问题和数千人死亡,并概述了对新型抗病毒药物的需求。本文综述了治疗冠状病毒感染的有效和选择性核苷药物的开发。到目前为止,大约有一半的抗病毒药物是基于核苷制造的。大多数基于核苷的药物已经被FDA批准。这为开发基于核苷的新型抗病毒药物提供了一个富有成果的领域。这篇综述描述了致病性SARS-CoV、MERS-CoV和SARS-CoV-2菌株的主要特征,介绍了它们的比较,考虑了有希望的方法来创建治疗冠状病毒感染的核苷药物,并对所有已知的核苷衍生物进行了系统评估,可以抑制冠状病毒在细胞中的繁殖。迄今为止,两种已知的核苷药物(瑞德西韦和法维皮拉韦)已被推荐用于治疗SARS-CoV-2感染,并发现了9种基于核苷及其类似物的击中化合物,其中一种有效抑制了SARS-CoV-2的复制,其他8种抑制了SARS-CoV的复制。
关键词: 冠状病毒,SARS-CoV-2,COVID-19,抗病毒治疗,RNA病毒,核苷类药物
Current Medicinal Chemistry
Title:Nucleoside Inhibitors of Coronaviruses
Volume: 28 Issue: 26
关键词: 冠状病毒,SARS-CoV-2,COVID-19,抗病毒治疗,RNA病毒,核苷类药物
摘要: Coronaviruses (CoVs) belong to a large family of zoonotic supercapsid viruses, including about 40 species of RNA-containing viruses with several strains capable of causing damage to the lungs and respiratory tract. The severe acute respiratory syndrome coronavirus (SARS-CoV) was responsible for the worldwide SARS outbreak in 2003. The rapid global spread of SARS-CoV-2 has been the cause of significant health concerns and thousands of deaths in 2019-2020 and outlined the need for novel antivirals. The present review is devoted to the development of effective and selective nucleoside drugs for the treatment of coronavirus infections. To date, about half of antivirals have been created based on nucleosides. The majority of drugs based on nucleosides have been approved by FDA. This indicates a fruitful area for the development of novel antivirals based on nucleosides. The review describes the main features of pathogenic SARS-CoV, MERS-CoV, and SARS-CoV-2 strains, presents their comparison, considers promising approaches to creating nucleoside drugs for the treatment of coronavirus infections and provides a systematic evaluation of all the known nucleoside derivatives, which inhibit the reproduction of coronaviruses in cells. To date, two known nucleoside drugs (Remdesivir, Favipiravir) have been recommended for the treatment of SARS-CoV-2 infection and nine hit compounds based on nucleosides and their analogues have been found, one of which efficiently suppressing SARS-CoV-2 replication and eight others inhibiting SARS-CoV replication.
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Cite this article as:
Nucleoside Inhibitors of Coronaviruses, Current Medicinal Chemistry 2021; 28 (26) . https://dx.doi.org/10.2174/0929867328666210208181724
DOI https://dx.doi.org/10.2174/0929867328666210208181724 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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