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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Irisin and Vascular Inflammation: Beneficial Effects of a Healthy Lifestyle Beyond Physical Activity

Author(s): Roberto Restuccia, Fulvio Perani, Giovanni Ficarra, Fabio Trimarchi, Alessandra Bitto* and Debora di Mauro

Volume 27, Issue 18, 2021

Published on: 08 February, 2021

Page: [2151 - 2155] Pages: 5

DOI: 10.2174/1381612827666210208154105

Price: $65

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Abstract

Vascular inflammation is responsible for many cardiovascular diseases and endothelial dysfunction is often the first trigger. Many factors can contribute to altering vascular homeostasis and despite that some risk factors cannot be changed, some lifestyle changes might dramatically improve vascular function. In this regard, physical activity has been identified as one of the most important interventions that can positively affect endothelial dysfunction. In recent years, the discovery of irisin, a novel myokine with pleiotropic effects, has caught the attention of many researchers. This review summarizes the most relevant intervention trials, evaluating irisin modifications in subjects with or without cardiovascular risk factors assigned to physical activity programs, to improve cardiovascular risk markers.

Keywords: Irisin, cardiovascular health, physical activity, vascular inflammation, endothelial dysfunction, irisin.

[1]
Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481(7382): 463-8.
[http://dx.doi.org/10.1038/nature10777] [PMID: 22237023]
[2]
Uysal N, Yuksel O, Kizildag S, et al. Regular aerobic exercise correlates with reduced anxiety and incresed levels of irisin in brain and white adipose tissue. Neurosci Lett 2018; 676: 92-7.
[http://dx.doi.org/10.1016/j.neulet.2018.04.023] [PMID: 29655944]
[3]
Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458(7241): 1056-60.
[http://dx.doi.org/10.1038/nature07813] [PMID: 19262508]
[4]
Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 2013; 8(4): e60563.
[http://dx.doi.org/10.1371/journal.pone.0060563] [PMID: 23593248]
[5]
Liu Y, Fu Y, Liu Z, et al. Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53. Biochim Biophys Acta Mol Basis Dis 2020; 1866(7): 165792.
[http://dx.doi.org/10.1016/j.bbadis.2020.165792] [PMID: 32251763]
[6]
Tari AR, Norevik CS, Scrimgeour NR, et al. Are the neuroprotective effects of exercise training systemically mediated? Prog Cardiovasc Dis 2019; 62(2): 94-101.
[http://dx.doi.org/10.1016/j.pcad.2019.02.003] [PMID: 30802460]
[7]
Ghahrizjani FA, Ghaedi K, Salamian A, et al. Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues. Gene 2015; 557(2): 123-9.
[http://dx.doi.org/10.1016/j.gene.2014.12.010] [PMID: 25497839]
[8]
Forouzanfar M, Rabiee F, Ghaedi K, et al. Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells. Cell Biol Int 2015; 39(5): 629-37.
[http://dx.doi.org/10.1002/cbin.10427] [PMID: 25572300]
[9]
Tu WJ, Qiu HC, Cao JL, Liu Q, Zeng XW, Zhao JZ. Decreased concentration of irisin is associated with poor functional outcome in ischemic stroke. Neurotherapeutics 2018; 15(4): 1158-67.
[http://dx.doi.org/10.1007/s13311-018-0651-2] [PMID: 30030698]
[10]
Wu H, Guo P, Jin Z, et al. Serum levels of irisin predict short-term outcomes in ischemic stroke. Cytokine 2019; 122: 154303.
[http://dx.doi.org/10.1016/j.cyto.2018.02.017] [PMID: 29472066]
[11]
Moreno M, Moreno-Navarrete JM, Serrano M, et al. Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. PLoS One 2015; 10(4): e0124100.
[http://dx.doi.org/10.1371/journal.pone.0124100] [PMID: 25897751]
[12]
Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med 2014; 233(2): 135-40.
[http://dx.doi.org/10.1620/tjem.233.135] [PMID: 24910199]
[13]
Tsuchiya Y, Ando D, Takamatsu K, Goto K. Resistance exercise induces a greater irisin response than endurance exercise. Metabolism 2015; 64(9): 1042-50.
[http://dx.doi.org/10.1016/j.metabol.2015.05.010] [PMID: 26081427]
[14]
Saleh O, Majeed MJ, Oreaby GM. Descriptive Consideration of Serum Irisin Levels Various Factors: Obesity, Type 2 Diabetes Mellitus, PreDiabetic Status, Gender, and Athletics. J Diabetes Metab 2014; 5: 471.
[http://dx.doi.org/10.4172/2155-6156.1000471]
[15]
Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 2011; 43(7): 1334-59.
[http://dx.doi.org/10.1249/MSS.0b013e318213fefb] [PMID: 21694556]
[16]
Scharhag-Rosenberger F, Meyer T, Wegmann M, et al. Irisin does not mediate resistance training-induced alterations in resting metabolic rate. Med Sci Sports Exerc 2014; 46(9): 1736-43.
[http://dx.doi.org/10.1249/MSS.0000000000000286] [PMID: 24566753]
[17]
Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans - results from a randomized controlled training trial. BMC Med 2013; 11: 235.
[http://dx.doi.org/10.1186/1741-7015-11-235] [PMID: 24191966]
[18]
Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015; 100(3): E453-7.
[http://dx.doi.org/10.1210/jc.2014-2416] [PMID: 25514098]
[19]
Löffler D, Müller U, Scheuermann K, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab 2015; 100(4): 1289-99.
[http://dx.doi.org/10.1210/jc.2014-2932] [PMID: 25625801]
[20]
Wrann CD, White JP, Salogiannnis J, et al. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab 2013; 18(5): 649-59.
[http://dx.doi.org/10.1016/j.cmet.2013.09.008] [PMID: 24120943]
[21]
Murawska-Cialowicz E, Wojna J, Zuwala-Jagiello J. Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women. J Physiol Pharmacol 2015; 66(6): 811-21.
[PMID: 26769830]
[22]
Zwetsloot KA, John CS, Lawrence MM, Battista RA, Shanely RA. High-intensity interval training induces a modest systemic inflammatory response in active, young men. J Inflamm Res 2014; 7: 9-17.
[http://dx.doi.org/10.2147/JIR.S54721] [PMID: 24520199]
[23]
Ruas JL, White JP, Rao RR, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell 2012; 151(6): 1319-31.
[http://dx.doi.org/10.1016/j.cell.2012.10.050] [PMID: 23217713]
[24]
Arhire LI, Mihalache L, Covasa M. Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome. Front Endocrinol (Lausanne) 2019; 10: 524.
[http://dx.doi.org/10.3389/fendo.2019.00524] [PMID: 31428053]
[25]
Tiano JP, Springer DA, Rane SG. SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. J Biol Chem 2015; 290(12): 7671-84.
[http://dx.doi.org/10.1074/jbc.M114.617399] [PMID: 25648888]
[26]
Blizzard LeBlanc DR, Rioux BV, Pelech C, et al. Exercise-induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial. Physiol Rep 2017; 5(23): e13539.
[http://dx.doi.org/10.14814/phy2.13539] [PMID: 29208692]
[27]
Lehti M, Donelan E, Abplanalp W, et al. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation 2013; 128(22): 2364-71.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001551] [PMID: 24170386]
[28]
Panagiotou G, Mu L, Na B, Mukamal KJ, Mantzoros CS. Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk. Metabolism 2014; 63(10): 1265-71.
[http://dx.doi.org/10.1016/j.metabol.2014.06.001] [PMID: 25060690]
[29]
Shao L, Meng D, Yang F, Song H, Tang D. Irisin-mediated protective effect on LPS-induced acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun 2017; 487(2): 194-200.
[http://dx.doi.org/10.1016/j.bbrc.2017.04.020] [PMID: 28396150]
[30]
Bi J, Zhang J, Ren Y, et al. Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases. JCI Insight 2020; 5(13): e136277.
[http://dx.doi.org/10.1172/jci.insight.136277] [PMID: 32516137]
[31]
Agh F, Mohammadzadeh Honarvar N, Djalali M, et al. Omega-3 Fatty Acid Could Increase One of Myokines in Male Patients with Coronary Artery Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. Arch Iran Med 2017; 20(1): 28-33.
[PMID: 28112528]
[32]
Vaughan RA, Garcia-Smith R, Bisoffi M, Conn CA, Trujillo KA. Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells. Lipids Health Dis 2012; 11: 142.
[http://dx.doi.org/10.1186/1476-511X-11-142] [PMID: 23107305]
[33]
Gmiat A, Mieszkowski J, Prusik K, et al. Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. Biogerontology 2017; 18(4): 535-48.
[http://dx.doi.org/10.1007/s10522-017-9694-8] [PMID: 28316011]
[34]
Korta P, Pocheć E, Mazur-Biały A. Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases. Medicina (Kaunas) 2019; 55(8): 485.
[http://dx.doi.org/10.3390/medicina55080485] [PMID: 31443222]
[35]
Kim H, Wrann CD, Jedrychowski M, et al. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Cell 2018; 175(7): 1756-1768.e17.
[http://dx.doi.org/10.1016/j.cell.2018.10.025] [PMID: 30550785]

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