摘要
背景:糖原合成激酶(GSK-3)抑制剂是治疗乳腺癌、肺癌、胃癌等多种癌症的新型药物。GSK-3的形态学检查未见病理改变。 目的:这篇综述描述了最近使用GSK-3抑制剂的程序,主要用于治疗结肠癌。进一步解释了不同GSK-3抑制剂治疗不同类型癌症的作用机制,并提出了一些可能有助于GSK-3抑制剂治疗包括结肠癌在内的癌症的进一步研究的附加机制。 结果:大多数癌变和癌前病变是由膜结合的花生四烯酸(AA)转化为二十烷酸所刺激的,这种转化促进了癌症的生存能力、增殖和扩散。GSK-3抑制剂可以恢复胃腺癌细胞对肿瘤坏死因子相关凋亡诱导配体(TRAIL)反应的敌意。GSK-3是糖原合成的最后一种酶,是一种丝氨酸/苏氨酸激酶,可磷酸化一系列异质性途径中的蛋白质中100多个不同序列。它是大量细胞过程的一个基本模块,在许多代谢过程和疾病中发挥着基本作用。许多被诊断为结肠癌的患者通过GSK-3抑制剂获得了长期缓解并获得了出色的生存率。 结论:在GSK-3抑制剂的这些机制被广泛应用之前,还需要进一步的评估和临床研究。只有在完成适当的临床研究和形态学检查后,才适合广泛应用。
关键词: GSK-3抑制剂,结肠癌,大肠癌,OMM,癌细胞凋亡,DMSO
Erratum In:
GSK-3 Inhibitors in the Regulation and Control of Colon
Carcinoma
图形摘要
Current Drug Targets
Title:GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma
Volume: 22 Issue: 13
关键词: GSK-3抑制剂,结肠癌,大肠癌,OMM,癌细胞凋亡,DMSO
摘要:
Background: Glycogen syntheis kinase (GSK-3) inhibitors are novel therapeutic agents for treating various types of cancer, such as breast, lung, and gastric cancer. No pathological changes have been found by the morphological examination of GSK-3.
Objectives: This review describes recent procedures using GSK-3 inhibitors, primarily in treating colon carcinoma. Furthermore, it also explains the mechanism of action of different GSK-3 inhibitors in treating various types of cancers and proposes some additional mechanisms may be useful for further research on GSK-3 inhibitors for cancers, including colon carcinoma.
Results: The majority of the cancerous and pre-cancerous lesions are stimulated by the transformation of membrane-bound arachidonic acid (AA) to eicosanoids, a transformation that promotes for the viability, proliferation, and spread of cancer. GSK-3 inhibitors can reinstate hostility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) responsiveness in gastric adenocarcinoma cells. GSK-3, the final enzyme in glycogen synthesis, is a serine/threonine kinase that phosphorylates varied sequences that are more than a hundred in number, within proteins in an array of heterogeneous pathways. It is an essential module of an exceptionally large number of cellular processes, playing a fundamental role in many metabolic processes and diseases. Many patients diagnosed with colon cancer achieve long-term remission with outstanding survival through the GSK-3 inhibitors.
Conclusion: Prior to the extensive application of these proposed mechanisms of GSK-3 inhibitor, further evaluation and clinical studies are needed. Only after the completion of appropriate clinical studies and morphological examinations, would extensive application be apprpriate.
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Cite this article as:
GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma, Current Drug Targets 2021; 22 (13) . https://dx.doi.org/10.2174/1389450122666210204203950
DOI https://dx.doi.org/10.2174/1389450122666210204203950 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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