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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

胆管癌治疗:最新进展

卷 21, 期 6, 2021

发表于: 04 February, 2021

页: [457 - 475] 页: 19

弟呕挨: 10.2174/1568009621666210204152028

价格: $65

摘要

背景：胆管癌(CCA)是第二常见的肝胆癌，预后不良。只有三分之一的阿胶病例是在手术阶段诊断出来的。然而，术后复发率很高。除了筛查可手术的个体外，迫切需要有效的治疗复发和晚期阿根瘤。现有治疗方法的治疗结果对明确临床指征和促进治疗策略的发展非常重要。 目的：本综述旨在从总生存期和无进展生存期两方面比较不同治疗方法的治疗效果。 方法：一百多篇同行评议的文章被查阅。我们比较了不同治疗方法之间的治疗效果，包括肿瘤切除术伴或不伴术后系统治疗，化疗包括folox，靶向治疗，如IDH1, K-RAS和FGFR抑制剂。值得注意的是，将现有治疗方法的科学依据和结果与标准的一线治疗方法进行了比较。 结果：早期CCAs应先行肿瘤切除手术，术后再行卡培他滨治疗。化疗可以作为术前不可切除的CCAs的选择。具有FGFR改变、IDH1和KRAS突变等遗传异常的不能手术的CCAs应考虑采用靶向治疗。氟嘧啶前药(S-1)/吉西他滨/顺铂和白蛋白紫杉醇/吉西他滨/顺铂显示良好的结果，提示三联方案在阿胶治疗中优于吉西他滨/顺铂。在没有基因改变的CCAs中，三联化疗应进一步与吉西他滨/顺铂进行比较。最近，吉西他滨加S-1被建议作为晚期/复发胆道癌便捷和等效的一线标准。 结论：这篇综述提供了新的靶向治疗和目前可用的治疗之间的比较结果。

关键词: 胆管癌，治疗， BILCAP

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图形摘要

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