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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

黄酮类化合物通过表观遗传调节多种机制克服对癌症化疗的耐药性

卷 21, 期 4, 2021

发表于: 02 February, 2021

页: [289 - 305] 页: 17

弟呕挨: 10.2174/1568009621666210203111220

价格: $65

摘要

耐药性是导致癌症化疗治疗失败的主要原因。已知表观遗传机制的失调会诱导化学抗性。据报道，许多编码癌症增殖、细胞凋亡、DNA 修复和药物流出的关键介质的基因在耐药癌细胞中因异常的 DNA 甲基化而失调。众所周知，催化组蛋白翻译后修饰的各种酶的失衡会改变染色质构型并调节多种耐药基因。癌细胞中 miRNA 特征的改变也会引起化学抗性。类黄酮是一大类天然存在的多酚化合物，广泛存在于植物、水果、蔬菜和传统草药中。人们对黄酮类化合物促进健康的作用越来越感兴趣。黄酮类化合物被证明可以通过表观遗传机制直接杀死耐药癌细胞或重新使它们对常规抗癌药物敏感。在这篇综述中，我们总结了目前黄酮类化合物通过纠正多种耐药机制的异常表观遗传调控来规避耐药性的发现。更多的研究，包括协同抗癌活性、给药顺序效应、正常细胞毒性和动物研究的评估，有必要确定黄酮类化合物与常规化疗药物联合治疗耐药癌症的全部潜力。

关键词: DNA 甲基化、表观遗传疗法、类黄酮、组蛋白修饰、多药耐药性、癌症化疗。

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