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Review Article

来自干细胞和祖细胞的细胞外囊泡用于无细胞再生疗法

卷 22, 期 2, 2022

发表于: 25 January, 2021

页: [120 - 131] 页: 12

弟呕挨: 10.2174/1566524021666210125114828

价格: $65

摘要

涉及干细胞或祖细胞的基于细胞的再生疗法被认为是治疗非传染性和退行性疾病的可能治疗方式。最近，基于细胞的疗法的再生结果与移植细胞而不是移植细胞本身释放的旁分泌因子和细胞外囊泡[EV]有关。EV包含的货物包括microRNA [miRNA]，mRNA以及蛋白质。它们在介导细胞间通讯中的作用已经在几项研究中得到承认。然而，EV中存在的miRNA，mRNA和蛋白质的再生潜力是一个正在进行的科学争论问题。在这篇综述中，我们讨论了细胞外囊泡[EV]作为基于干细胞的疗法的替代方案，以治疗一些非传染性和退行性疾病。此外，我们还提出，细胞的预处理可以帮助产生富含特定miRNA，mRNA和/或蛋白质的EV，这些蛋白质可以支持靶器官的成功再生。

关键词: 外泌体，间充质干细胞，微囊泡，miRNA，mRNA，旁分泌因子。

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