摘要
光动力疗法 (PDT) 作为一种临床上批准的用于治疗包括癌症在内的各种疾病的方式,近年来取得了很大进展。通过在病理区域优先积累无毒光敏剂(PSs),并在适当波长的光源局部照射下原位产生细胞毒性活性氧(ROS),PDT以双选择性方式起作用。在过去的几十年中,许多关于 PDT 的研究和评论主要集中在 PDT 中可激活的 PSs 和新兴的 PSs。然而,据我们所知,系统介绍光源的文章很少,关于 PDT 中靶向策略的报道也有限。本综述全面总结了 PDT 中应用的各种光源以及典型的增强靶向策略,并分别概述了它们的优缺点。还部分介绍和讨论了光源的临床应用和未来前景。
关键词: 光动力疗法、光敏剂、活性氧 (ROS)、光源、肿瘤疗法、靶向。
Current Medicinal Chemistry
Title:A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy
Volume: 28 Issue: 31
关键词: 光动力疗法、光敏剂、活性氧 (ROS)、光源、肿瘤疗法、靶向。
摘要: Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual-selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.
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Cite this article as:
A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867328666210121122106
DOI https://dx.doi.org/10.2174/0929867328666210121122106 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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