Review Article

药丸剂型的综合评价

卷 22, 期 10, 2021

发表于: 20 January, 2021

页: [1183 - 1195] 页: 13

弟呕挨: 10.2174/1389450122999210120204248

价格: $65

摘要

口服给药途径因其多功能性、便利性以及最重要的患者依从性而被广泛接受和期望。 与单一单位剂型相比,颗粒和丸剂等多颗粒系统更有利,因为它们能够在胃肠道中更均匀地分布药物。 当前的论文侧重于颗粒、相关的优缺点、各种造粒技术及其表征。 它还侧重于如何将药丸用于药物递送受控和缓释制剂。 它完全强调了可用于微丸形成的药物和赋形剂、已上市的制剂以及与微丸相关的研究。

关键词: 丸剂、多单元剂型、丸剂化技术、流动性、速释、缓释。

« Previous
图形摘要

[1]
Debotton N, Dahan A. Applications of polymers as pharmaceutical excipients in solid oral dosage forms. Med Res Rev 2017; 37(1): 52-97.
[http://dx.doi.org/10.1002/med.21403] [PMID: 27502146]
[2]
Ramu S, Ramakrishna G, Balaji M, Kondala K, Haranadh S. Multiple unit drug delivery system: pelletization techniques. Am J Adv Drug Deliv 2013; 1(1): 11-21.
[3]
Aleksovski A, Dreu R, Gašperlin M, Planinšek O. Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups. Expert Opin Drug Deliv 2015; 12(1): 65-84.
[http://dx.doi.org/10.1517/17425247.2014.951633] [PMID: 25200881]
[4]
Chen T, Li J, Chen T, Sun CC, Zheng Y. Tablets of multi-unit pellet system for controlled drug delivery. J Control Release 2017; 262: 222-31.
[http://dx.doi.org/10.1016/j.jconrel.2017.07.043] [PMID: 28774838]
[5]
Dukić-Ott A, Thommes M, Remon JP, Kleinebudde P, Vervaet C. Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review. Eur J Pharm Biopharm Off J Arbeitsgemeinschaft fur Pharm Verfahrenstechnik eV 2009; 71(1): 38-46.
[6]
Malkin R. On site service factor works for minetec. AusIMM Bulletin 2006.
[7]
Rashmitha NM, Somashekhar CN, Mani TT. Pellets and Pelletization. World J Pharm Pharm Sci 2018; 7(10): 1570-80.
[8]
Patel HP, Patel JK, Patel RR, Patel MP. Pellets: A general overview. Int J Curr Res Rev 2010; 2(6): 21-31.www.ijcrr.com
[9]
Ahir AA, Mali SS, Hajare AA, Bhagwat DA, Patrekar PV. Pelletization technology: Methods and applications - A review. Res J Pharm Technol 2015; 8(2): 131-8.
[http://dx.doi.org/10.5958/0974-360X.2015.00023.2]
[10]
Tunón A, Börjesson E, Frenning G, Alderborn G. Drug release from reservoir pellets compacted with some excipients of different physical properties. Eur J Pharm Sci 2003; 20(4-5): 469-79.
[http://dx.doi.org/10.1016/j.ejps.2003.09.009] [PMID: 14659491]
[11]
Sawicki W, Łunio R. Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D. Eur J Pharm Biopharm 2005; 60(1): 153-8.
[http://dx.doi.org/10.1016/j.ejpb.2004.11.003] [PMID: 15848067]
[12]
Deb R, Ahmed AB. Pellets and Pelletization Techniques: a Critical Review. Int Res J Pharm 2016; 4(4): 90-5.
[http://dx.doi.org/10.7897/2230-8407.04414]
[13]
Hirjau M, Nicoara AC, Hirjau V, Lupuleasa D. Pelletization techniques used in pharmaceutical fields. Pract Farm 2011; 4(3-4): 206-11.http://www.tandfonline.com/doi/pdf/10.1081/E-EPT3-100200034
[14]
Clarke GM, Newton JM, Short MB. Comparative gastrointestinal transit of pellet systems of varying density. Int J Pharm 1995; 114(1): 1-11.
[http://dx.doi.org/10.1016/0378-5173(94)00200-O]
[15]
O’connor R, Schwartz J, Spheronization II. Drug release from drug-diluent mixtures. Drug Dev Ind Pharm 2008; 11: 1837-57.
[http://dx.doi.org/10.3109/03639048509057702]
[16]
Fielden KE, Newton JM, Rowe RC. The influence of moisture content on spheronization of extrudate processed by a ram extruder. Int J Pharm 1993; 97(1–3): 79-92.
[http://dx.doi.org/10.1016/0378-5173(93)90128-3]
[17]
Digenis G. The in vivo behavior of multiparticulate versus single-unit dose formulations. CAPSUGEL 1994; 333-55.
[http://dx.doi.org/10.1201/b14855-14]
[18]
Korakianiti ES, Rekkas DM, Dallas PP, Choulis NH. Optimization of the pelletization process in a fluid-bed rotor granulator using experimental design. AAPS PharmSciTech 2000; 1(4)
[http://dx.doi.org/10.1208/pt010435] [PMID: 14727900]
[19]
Flament MP, Dupont G, Leterme P, Farah N, Gayot A. Development of 400 microm pellets by extrusion-spheronization: application with Gelucire 50/02 to produce a “sprinkle” form. Drug Dev Ind Pharm 2004; 30(1): 43-51.
[http://dx.doi.org/10.1081/DDC-120027510] [PMID: 15000429]
[20]
RB A, GN S, CHANDY Va. Study on Different Pellet Formation Techniques and Its Evaluation Parameters-a Review. Int J Curr Pharm Res 2019; 11(2): 7-13.
[21]
Vamshi KT, Reddy MS. Formulation and evaluation Ofenteric coated pellets of Rifampicin and Isoniazid with improved Rifampicin stability. Asian J Pharm Clin Res 2014; 7: 154-6.
[22]
Supriya P, Rajni B, Rana AC. Pelletization Techniques: a Literature Review. Int Res J Pharm 2012; 3(3): 43-7.
[23]
Review A. Int J Res Pharm Chem 2017; 7(2): 141-7.www.ijrpc.com/files/12-04-17/02.pdf
[24]
Politis SN, Rekkas DM. Pelletization processes for pharmaceutical applications: a patent review. Recent Pat Drug Deliv Formul 2011; 5(1): 61-78.
[http://dx.doi.org/10.2174/187221111794109493] [PMID: 21143125]
[25]
Sirisha VRK, Sri KV, Suresh K, et al. Review of pellets and pelletization process - a multiparticulate drug delivery system. Int J Pharm Sci Res 2013; 4(6): 2145-58.
[26]
Hede PD. Advanced granulation theory at particle level. Ventusdk 2006; 1-62.https://www.mobt3ath.com/uplode/book/book-22287.pdf
[27]
Kammili L. Pelletization Technology : a Quick Review. Ijpsr 2011; 2(6): 1337-55.
[28]
Kristensen HG, Schaefer T. Granulation: A review on pharmaceutical wet-granulation. Drug Dev Ind Pharm 1987; 13(4-5): 803-72.
[http://dx.doi.org/10.3109/03639048709105217]
[29]
Kumari MH, Samatha K, Balaji A, Uma Shankar MS. Recent novel advandcements in pellet formulation: A review. Int J Pharm Sci Res 2013; 4(10): 3803-22.http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L370177114%5Cnhttp://www.ijpsr.com/V4I10/12
[30]
Muley S, Nandgude T, Poddar S. Extrusion–spheronization a promising pelletization technique: In-depth review. Asian J Pharm Sci [Internet] 2016; 11(6): 684-99.
[http://dx.doi.org/10.1016/j.ajps.2016.08.001]
[31]
Bhaskaran S, Lakshmi PK. Extrusion spheronization -A review. Int J Pharm Tech Res 2010; 2(4): 2429-33.
[32]
Kandukuri JM, Allenki V, Eaga CM, Keshetty V, Jannu KK. Pelletization techniques for oral drug delivery. Int J Pharm Sci Drug Res 2009; 1(2): 63-70. www.ijpsdr.com
[33]
Gupta AM, Shivhare UD, Suruse PB. Different aspects of pellets formulation and their evaluation. Int J Pharm Phytopharm Res 2015; 4(6): 331-6.
[34]
Hamdani J, Moës AJ, Amighi K. Development and evaluation of prolonged release pellets obtained by the melt pelletization process. Int J Pharm 2002; 245(1-2): 167-77.
[http://dx.doi.org/10.1016/S0378-5173(02)00348-4] [PMID: 12270253]
[35]
Kadam V, Gattani S. Effect of curing time on ph and time dependant coated pellets. Int J Heal Res 2010; 9: 2.
[http://dx.doi.org/10.4314/ijhr.v2i1.55394]
[36]
Rao BS. Studies on release of rifampicin from sintered matrix tablets. Indian J Pharm Sci 2001; 63: 371-8.
[37]
Aitken-Nichol C, Zhang F, McGinity JW. Hot melt extrusion of acrylic films. Pharm Res 1996; 13(5): 804-8.
[http://dx.doi.org/10.1023/A:1016076306279] [PMID: 8860442]
[38]
Repka MA, Gerding TG, Repka SL, McGinity JW. Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion. Drug Dev Ind Pharm 1999; 25(5): 625-33.
[http://dx.doi.org/10.1081/DDC-100102218] [PMID: 10219532]
[39]
Swarbrick J, Boylan JC. Encyclopedia of pharmaceutical technology. CRC Press 2000; 20.(supplement 3)
[40]
Cheboyina S, Chambliss WG, Wyandt CM. A novel freeze pelletization technique for preparing matrix pellets. Pharm Technol 2004; 28(10): 98-110.
[41]
Aher U, Shelke T, Patel E. Recently used technologies in Pellet Formulation - A Review. PharmaTutor 2017; 5(7): 22-30.https://www.pharmatutor.org/articles/recently-used-technologiesin-pellet-formulation-a-review
[42]
Shaikh DM, Shende MA, Shaikh AM. Formulation development and evaluation of gastro retentive mucoadhesive tablets using synthetic polymers. Int J Res Pharm Biomed Sci 2013; 4(4): 1264-71.
[43]
Gurram RK, Gandra S, Shastri NR. Design and optimization of disintegrating pellets of MCC by non-aqueous extrusion process using statistical tools. Eur J Pharm Sci 2016; 84: 146-56.
[http://dx.doi.org/10.1016/j.ejps.2016.01.021] [PMID: 26812204]
[44]
Roblegg E, Ulbing S, Zeissmann S, Zimmer A. Development of lipophilic calcium stearate pellets using ibuprofen as model drug. Eur J Pharm Biopharm 2010; 75(1): 56-62.
[http://dx.doi.org/10.1016/j.ejpb.2010.01.005] [PMID: 20080179]
[45]
Hadi MA, Avanapu SR. Development of a Novel Enteric Coated Extended Release Pellets using Model NSAID Flurbiprofen 2015.
[46]
Speer I, Lenhart V, Preis M, Breitkreutz J. Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets. Int J Pharm 2019; 554(554): 149-60.
[http://dx.doi.org/10.1016/j.ijpharm.2018.11.013] [PMID: 30414477]
[47]
Vanitha K, Venkataswamy M, Niharika S, Ramesh A. Formulation Development and Evaluation of Mebeverine extended release Pellets. Asian J Pharm Technol 2018; 8(2): 71.
[http://dx.doi.org/10.5958/2231-5713.2018.00011.9]
[48]
Bae J, Park JW. Formulation and pharmacokinetic evaluation of controlled-release oxybutynin tablets in dogs. Trop J Pharm Res 2015; 14(3): 363-9.
[http://dx.doi.org/10.4314/tjpr.v14i3.2]
[49]
Han X, Wang L, Sun Y, et al. Preparation and evaluation of sustained-release diltiazem hydrochloride pellets. Asian J Pharm Sci [Internet] 2013; 8(4): 244-51.
[http://dx.doi.org/10.1016/j.ajps.2013.09.007]
[50]
Xu Y-C, Wang H-G. Study of isosorbide dinitrate sustained release matrix pellets prescription screening and drug release mechanism. Chin J Antibiot 2014; 8: 615-9.
[51]
Radha GV, Trideva Sastri K, Manaswini N, Likhitha B. Formulation development and evaluation of sustained release gastroretentive tablet of emtricitabine. Int J Appl Pharm 2019; 11(5): 236-40.
[http://dx.doi.org/10.22159/ijap.2019v11i5.34840]
[52]
Battu S, Yalavarthi PR, Subba Reddy GV, Uma Maheswara Rao V, Jyothshna Devi K, Vadlamudi HC. Design and assessment of pulsatile technology based chronomodulated delivery systems of nifedipine. Beni-Suef Univ J Basic Appl Sci [Internet] 2018; 7(4): 441-5.
[http://dx.doi.org/10.1016/j.bjbas.2018.03.012]
[53]
Zeeshan F, Bukhari NI. Development and evaluation of a novel modified-release pellet-based tablet system for the delivery of loratadine and pseudoephedrine hydrochloride as model drugs. AAPS PharmSciTech 2010; 11(2): 910-6.
[http://dx.doi.org/10.1208/s12249-010-9456-2] [PMID: 20496016]
[54]
Bruce LD, Koleng JJ, McGinity JW. The influence of polymeric subcoats and pellet formulation on the release of chlorpheniramine maleate from enteric coated pellets. Drug Dev Ind Pharm 2003; 29(8): 909-24.
[http://dx.doi.org/10.1081/DDC-120024187] [PMID: 14570312]
[55]
Jedinger N, Schrank S, Fischer JM, Breinhälter K, Khinast J, Roblegg E. Development of an abuse- and alcohol-resistant formulation based on hot-melt extrusion and film coating. AAPS PharmSciTech 2016; 17(1): 68-77.
[http://dx.doi.org/10.1208/s12249-015-0373-2] [PMID: 26206403]
[56]
Kushare SU, Phatak AA, Chaudhari PD. Development and evaluation of a novel modified release pellet-based system for the delivery of desloratadine and pseudoephedrine hydrochloride. Asian J Pharm 2011; 5(4): 203-8.
[http://dx.doi.org/10.4103/0973-8398.97111]
[57]
Zhu L, Kumar V, Banker GS. Examination of aqueous oxidized cellulose dispersions as a potential drug carrier. II. In vitro and in vivo evaluation of phenylpropanolamine release from microparticles and pellets. AAPS PharmSciTech 2004; 5(4)
[http://dx.doi.org/10.1208/pt050470] [PMID: 15760067]
[58]
Chakravarthy KK, Younus M, Shaik S, Pisipati SVV. Formulation and evaluation of enteric coated pellets of omeprazole. Int J Drug Dev Res 2012; 4(4): 257-64.
[59]
Uthirapathy S. Formulation and characterization of lansoprazole dr pellets by fluid bed coating technique 2017.
[60]
Fan R, Sun Y, Li B, Yang R, Ma W, Sun J. Preparation and stability investigation of tamsulosin hydrochloride sustained release pellets containing acrylic resin polymers with two different techniques. Asian J Pharm Sci 2017; 12(2): 193-201.
[http://dx.doi.org/10.1016/j.ajps.2016.09.003] [PMID: 32104330]
[61]
Akhgari A, Abbaspour MR, Pirmoradi S. Preparation and evaluation of pellets using acacia and tragacanth by extrusion-spheronization. Daru 2011; 19(6): 417-23.
[PMID: 23008687]
[62]
Chaudhari PM, Chaudhari PD. Formulation and evaluation of multiparticulate system for chronotherapeutic delivery of salbutamol sulphate. J Pharm Bioallied Sci 2012; 4(Suppl. 1): S71-3.
[http://dx.doi.org/10.4103/0975-7406.94144] [PMID: 23066213]
[63]
Bajwa PS, Sharma J, Sharma S, Bhargava A. Development and In vitro-in vivo characterization of chronomodulated multi-particulate drug delivery system of Terbutaline sulphate for treatment of nocturnal asthma by box-Behnken statistical design. J Appl Pharm Sci 2017; 7(11): 33-42.
[64]
Sreelesh B, Avari J, Nagpal M. Multiparticulate enteric coated formulation of chloroquine phosphate for better patient compliance. Int. J Chem Sci 2010; 8(4): 2386-94.
[65]
Kapoor B, Subbarao G. Formulation development and characterization of itraconazole granules. Int J Pharm Sci Nanotechnol 2011; 4 10.37285/ijpsn.2011.4.3.9.
[66]
Park ES, Lee DS, Kwon SY, Chi SC. A new formulation of controlled release amitriptyline pellets and its in vivo/in vitro assessments. Arch Pharm Res 2003; 26(7): 569-74.
[http://dx.doi.org/10.1007/BF02976883] [PMID: 12934651]
[67]
Cheng G, An F, Zou MJ, Sun J, Hao XH, He YX. Time- and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World J Gastroenterol 2004; 10(12): 1769-74.
[http://dx.doi.org/10.3748/wjg.v10.i12.1769] [PMID: 15188503]
[68]
Wang L, Wang J, Lin X, Tang X. Preparation and in vitro evaluation of gliclazide sustained-release matrix pellets: formulation and storage stability. Drug Dev Ind Pharm 2010; 36(7): 814-22.
[http://dx.doi.org/10.3109/03639040903520967] [PMID: 20345281]
[69]
K K, NV Gupta, Gowda D, Sivadasu P. Formulation of immediate release (Ir) atorvastatin calcium pellets and sustained release (sr) glibenclamide for fixed-dose combination dosage form. Asian J Pharm Clin Res 2018; 11: 159.
[http://dx.doi.org/10.22159/ajpcr.2018.v11i12.26629]
[70]
Mehmood Y. Combination of allopurinol ’ and sustained release diclofenac sodium for treatment of gout. Int J Sci Res (Ahmedabad) 2014; 3(5): 46-52.
[71]
Judson GJ, Babidge PJ, Vawser MJ, Chen ZH, Sansom LN. Long acting vitamin B12 pellet for preventing cobalt deficiency. Asian-Australas J Anim Sci 2000; 13(Suppl. 1): 154.
[72]
Cunha TA, Serpa RC, de Oliveira APM, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech 2013; 14(3): 1150-7.
[http://dx.doi.org/10.1208/s12249-013-0006-6] [PMID: 23897034]
[73]
Fielden KE, Newton JM, Rowe RC. Movement of liquids through powder beds. Int J Pharm 1992; 79(1): 47-60.http://www.sciencedirect.com/science/article/pii/037851739290092G
[http://dx.doi.org/10.1016/0378-5173(92)90092-G]
[74]
Mesiha MS, Valltés J. A screening study of lubricants in wet powder masses suitable for extrusion-spheronization. Drug Dev Ind Pharm 1993; 19(8): 943-59.
[http://dx.doi.org/10.3109/03639049309062993]
[75]
Marvola M, Nykänen P, Rautio S, Isonen N, Autere A. Enteric polymers as binders and coating materials in multiple-unit site-specific drug delivery systems. Eur J Pharm Sci 1999; 7(3): 259-67.
[http://dx.doi.org/10.1016/S0928-0987(98)00032-3] [PMID: 9845814]
[76]
Podczeck F, Newton JM. A shape factor to characterize the quality of spheroids. J Pharm Pharmacol 1994; 46(2): 82-5.
[http://dx.doi.org/10.1111/j.2042-7158.1994.tb03745.x] [PMID: 8021810]
[77]
Newton JM, Chapman SR, Rowe RC. The influence of process variables on the preparation and properties of spherical granules by the process of extrusion and spheronisation. Int J Pharm 1995; 120(1): 101-9.http://www.sciencedirect.com/science/article/pii/0378517394004277
[http://dx.doi.org/10.1016/0378-5173(94)00427-7]
[78]
Harrison PJ, Newton JM, Rowe RC. The characterization of wet powder masses suitable for extrusion/spheronization. J Pharm Pharmacol 1985; 37(10): 686-91.
[http://dx.doi.org/10.1111/j.2042-7158.1985.tb04943.x] [PMID: 2867135]
[79]
Noche C, Huet de Barochez B, Brossard C, Horvath S. Optimizing the manufacturing process for controlled release pellets. Pharmaceutical Technology Europe 1994; 6: 39.
[80]
Abhishek P. Formulation and evaluation of metoprolol succinate extended release pellets. Doctoral dissertation, JKK Munirajah Medical Research Foundation College of Pharmacy: Komarapalayam 2012.
[81]
Woodruff CW, Nuessle NO. Effect of processing variables on particles obtained by extrusion-spheronization processing. J Pharm Sci 1972; 61(5): 787-90.
[http://dx.doi.org/10.1002/jps.2600610525] [PMID: 5035792]
[82]
Cheboyina S, Wyandt CM. Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique I. Formulation and process variables affecting pellet characteristics. Int J Pharm 2008; 359(1-2): 158-66.http://www.sciencedirect.com/science/article/pii/S037851730800269X
[http://dx.doi.org/10.1016/j.ijpharm.2008.04.011] [PMID: 18499369]
[83]
Ravella VN, Nadendla RR, Kesari NC. Design and evaluation of sustained release pellets of aceclofenac. J Pharm Res 2013; 6(5): 525-31.
[http://dx.doi.org/10.1016/j.jopr.2013.04.040]
[84]
Puranik PK, Khan FM. Formulation and evaluation of Aceclofenac loaded SR matrix pellets: Extrusion spheronization. Int J Pharm Pharm Sci 2013; 5(Suppl. 3): 781-9.
[85]
Sachdeva V, Alam MS, Kumar R, Kataria MK. Oral multiunit pellet extended release dosage form: A review. Int Curr Pharm J 2013; 2(10): 177-84.
[http://dx.doi.org/10.3329/icpj.v2i10.16413]
[86]
Andreazza IF, Ferraz HG. Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D. Braz Arch Biol Technol 2011; 54(4): 315-20.
[http://dx.doi.org/10.1590/S1516-89132011000200013]
[87]
Mehta AM. Evaluation and characterization of pellets Pharmaceutical pelletization technology. New York: Marcel Dekker 1989; pp. 241-65.
[88]
Gowda D, Bathool A, Khan M, Gupta V. Pelletization as a key tool for oral drug delivery :A review. J Pharm Sci 2011; 4: 3282-6.
[89]
Chatlapalli R, Rohera BD. Physical characterization of HPMC and HEC and investigation of their use as pelletization aids. Int J Pharm 1998; 161(2): 179-93.
[http://dx.doi.org/10.1016/S0378-5173(97)00350-5]
[90]
Ahmad A, Khan MU, Elkalmi RM, et al. Job satisfaction among Indian pharmacists: An exploration of affecting variables and suggestions for improvement in pharmacist role. Indian J Pharm Educ Res 2016; 50(1): 9-16.
[http://dx.doi.org/10.5530/ijper.50.1.2]
[91]
Reddy S, Das P, Das H, Sci AG-JPB. 2011 undefined MUPS (multiple unit pellet system) tablets–a brief review 2011.
[92]
Holtmann G, Talley NJ, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia. N Engl J Med 2006; 354(8): 832-40.
[http://dx.doi.org/10.1056/NEJMoa052639] [PMID: 16495395]
[93]
Iwanaga Y, Miyashita N, Saito T, Morikawa K, Itoh Z. Gastroprokinetic effect of a new benzamide derivative itopride and its action mechanisms in conscious dogs. Jpn J Pharmacol 1996; 71(2): 129-37.
[http://dx.doi.org/10.1254/jjp.71.129] [PMID: 8835639]
[94]
Yajima T, Nogata A, Demachi M, et al. Particle design for taste-masking using a spray-congealing technique. Chem Pharm Bull (Tokyo) 1996; 44(1): 187-91.
[http://dx.doi.org/10.1248/cpb.44.187]
[95]
Costa FO, Sousa JJS, Pais AACC, Formosinho SJ. Comparison of dissolution profiles of Ibuprofen pellets. J Control Release 2003; 89(2): 199-212.
[http://dx.doi.org/10.1016/S0168-3659(03)00033-6] [PMID: 12711444]
[96]
Dashevsky A, Kolter K, Bodmeier R. pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP. Eur J Pharm Biopharm 2004; 58(1): 45-9.
[http://dx.doi.org/10.1016/j.ejpb.2004.03.013] [PMID: 15207536]
[97]
Vonderscher J, Meinzer A. Transplantation proceedings. Rationale for the development of sandimmune neoral. International congress on cyclosporine. New York, NY. Elsevier Science 1994; pp. 1994-03-29; 26: 2925-7.
[98]
Atyabi F, Majzoob S, Iman M, Salehi M, Dorkoosh F. In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon. Carbohydr Polym 2005; 61(1): 39-51.
[http://dx.doi.org/10.1016/j.carbpol.2005.02.005]
[99]
Liu L, Fishman ML, Kost J, Hicks KB. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003; 24(19): 3333-43.http://www.sciencedirect.com/science/article/pii/S0142961203002138
[http://dx.doi.org/10.1016/S0142-9612(03)00213-8] [PMID: 12763460]
[100]
Vani M, Meena A, Savio FG, Priya M. Design and evaluation of gastro retentive floating beads of ranitidine hydrochloride. Int J Pharma Bio Sci 2010; 1: 1-4.
[101]
Trivedi ND, Trivedi UN, Patel MM, Jayvadan P, Bhandari A. Preparation and Evaluation of Floating Matrix Tablet of Ranitidine. Am J Drug Discov Dev 2011; 1: 8-23.
[http://dx.doi.org/10.3923/ajdd.2011.8.23]
[102]
Rao Y, Bandari S, Mittapalli R, Gannu R. Orodispersible tablets: An overview. Asian J Pharm 2008; 2(1): 2.
[http://dx.doi.org/10.4103/0973-8398.41557]
[103]
Hamed R, Omran H. Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib. J Drug Deliv Sci Technol 2020; 55: 101419.
[104]
Abdel-Gawad R, Osman R, Awad GAS, Mortada N. Lecithin-based modified soft agglomerate composite microparticles for inhalable montelukast: Development, tolerability and pharmacodynamic activity. Powder Technol 2020; 360: 1167-76.
[http://dx.doi.org/10.1016/j.powtec.2019.11.029]
[105]
Flórez-Castillo JM, Ropero-Vega JL, Perullini M, Jobbágy M. Biopolymeric pellets of polyvinyl alcohol and alginate for the encapsulation of Ib-M6 peptide and its antimicrobial activity against E. coli. Heliyon 2019; 5(6): e01872.
[http://dx.doi.org/10.1016/j.heliyon.2019.e01872] [PMID: 31194071]
[106]
Nejati L, Kalantari F, Bavarsad N, Saremnejad F, Moghaddam PT, Akhgari A. Investigation of using pectin and chitosan as natural excipients in pellet formulation. Int J Biol Macromol 2018; 120(Pt A): 1208-15.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.08.129] [PMID: 30165148]
[107]
Vo AQ, Feng X, Pimparade M, et al. Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion. Eur J Pharm Sci 2017; 102: 71-84.http://www.sciencedirect.com/science/article/pii/S0928098717301173
[http://dx.doi.org/10.1016/j.ejps.2017.02.040] [PMID: 28257881]
[108]
Riekes MK, Dereymaker A, Berben P, Augustijns P, Stulzer HK, Van den Mooter G. Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters. Int J Pharm 2017; 520(1-2): 49-58.http://www.sciencedirect.com/science/article/pii/S0378517317300625
[http://dx.doi.org/10.1016/j.ijpharm.2017.01.053] [PMID: 28153650]
[109]
de Alencar RG, de Oliveira AC, Lima EM, da Cunha-Filho MSS, Taveira SF, Marreto RN. Compacted multiparticulate systems for colon-specific delivery of ketoprofen. AAPS PharmSciTech 2017; 18(6): 2260-8.
[http://dx.doi.org/10.1208/s12249-016-0700-2] [PMID: 28074422]
[110]
Reddy GLN, Rajnarayana K, Jayaveera KN. Development and in vitro-in vivo evaluation of extended-release multiple-unit pellet system tablets of metoprolol succinate. Asian J Pharm 2016; 10(1): S39-42.
[111]
Li J, Chai H, Li Y, et al. A three-pulse release tablet for amoxicillin: Preparation, pharmacokinetic study and physiologically based pharmacokinetic modeling. PLoS One 2016; 11(8)
[http://dx.doi.org/10.1371/journal.pone.0160260] [PMID: 27479702]
[112]
Novikova A, Carstensen JM, Rades T, Leopold PDCS. Multispectral UV imaging for surface analysis of MUPS tablets with special focus on the pellet distribution. Int J Pharm 2016; 515(1-2): 374-83.
[http://dx.doi.org/10.1016/j.ijpharm.2016.09.087] [PMID: 27702695]
[113]
Li X, Xu DS, Li M, Liu L, Heng P. Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. Drug Dev Ind Pharm 2016; 42(5): 788-95.
[http://dx.doi.org/10.3109/03639045.2015.1075034] [PMID: 26289006]
[114]
Yang Z, Yu J, Yang T, et al. A method for the preparation of sustained release-coated Metoprolol Succinate pellet-containing tablets. Pharm Dev Technol 2016; 21(8): 943-50.
[http://dx.doi.org/10.3109/10837450.2015.1081612] [PMID: 26334840]
[115]
Zaman M, Saeed-Ul-Hassan S, Sarfraz RM, et al. Pellets and pelletization: Emerging trends in the pharma industry. Acta Pol Pharm -. Acta Pol Pharm 2016; 73(6): 1415-25.
[PMID: 29634093]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version331msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[00:19:45] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[00:19:45] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[00:19:45] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[00:19:45] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (101ms)time
  • Application (230ms)time
  • 1 x Application (69.57%)
    230ms
    1 x Booting (30.43%)
    101ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    41 statements were executed, 4 of which were duplicates, 37 unique. Show only duplicated160ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51156756','',1,1740529185,1740529185) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740529185
      940μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51156756','/article/113506/cn',1,1740529185,1740529185)
      140μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51156756 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51156756) limit 1
      11.68msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51156756
      • 1: 51156756
      • 2: 51156756
      • 3: 51156756
      • 4: 51156756
      • 5: 51156756
      • 6: 51156756
      • 7: 51156756
      • 8: 51156756
      • 9: 51156756
      • 10: 51156756
      • 11: 51156756
      • 12: 51156756
      • 13: 51156756
      • 14: 51156756
      • 15: 51156756
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=113506
      630μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 13 limit 1
      730μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 13
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=13) and sj.journal_id!=13 group by `j`.`nid`) as `aggregate_table`
      960μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=13) and sj.journal_id!=13 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      790μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=13) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.19msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=13) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.08msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '113506'
      250μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 113506
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '113506'
      4.64msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 113506
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '113506' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.3msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 113506
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      290μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      410μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 13 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      26.25msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 13 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      12.54msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 13 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      10.57msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 113506 limit 1
      200μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 113506
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 113506 and content_type = 'article' order by status desc limit 1
      840μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 258 and cd.sub_disease_id = 402 and content_id!=113506 and cd.content_type = 'article' order by rand() limit 20
      55.99msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 190527 limit 1
      200μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 190527
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      190μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CDT' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      260μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CDT
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '113506' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '10714' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2949' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      250μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2949)
      7.39msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10714) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10714) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10714)
      540μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 113506) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 113506) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51156756 and j.to_ip >=51156756 )) and ((j.from_date <= 1740529185 and j.to_date >= 1740529185 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 113506)
      550μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '1183' and is_uploaded = 1 and issue_id = 10714 order by cast(first_page as SIGNED) desc limit 1
      430μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 1183
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '1195' and is_uploaded = 1 and issue_id = 10714 order by cast(first_page as SIGNED) asc limit 1
      330μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 1195
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'cn'
      150μsalphaeurekaselec_live_10_06_2022ArticleController.php#2486
      Bindings
      • 0: cn
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2486
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 2
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 2
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2487
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `multilanguage_article` where (`language_id` = 2 and `article_id` = 113506)
      5.59msalphaeurekaselec_live_10_06_2022ArticleController.php#2488
      Bindings
      • 0: 2
      • 1: 113506
      Backtrace
      • 15. app/Http/Controllers/ArticleController.php:2488
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `keyword` from `multilanguage_keywords` where (`language_id` = 2 and `article_id` = 113506)
      2.41msalphaeurekaselec_live_10_06_2022ArticleController.php#2489
      Bindings
      • 0: 2
      • 1: 113506
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2489
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT_WS(' ',au.last_name, ', ', ifnull(au.initials,''), ' ', au.first_name) as authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `multilanguage_authors` as `au` left join `multilanguage_author_affiliation` as `af` on `au`.`id` = `af`.`author_id` where `au`.`article_id` = 113506 group by `au`.`id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3.76msalphaeurekaselec_live_10_06_2022MultiLangAuthor.php#30
      Bindings
      • 0: 113506
      Backtrace
      • 13. app/Models/MultiLangAuthor.php:30
      • 14. app/Http/Controllers/ArticleController.php:2493
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `multilanguage_journal`.`title` from `multilanguage_journal` where `multilanguage_journal`.`journal_id` = 13 and `language_id` = 2
      180μsalphaeurekaselec_live_10_06_2022ArticleController.php#2495
      Bindings
      • 0: 13
      • 1: 2
      Backtrace
      • 13. app/Http/Controllers/ArticleController.php:2495
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `id` from `multilanguage_article` where `article_id` = 113506 limit 1
      2.09msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 113506
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 13 and `b`.`banner_from_date` <= 1740529185 and `b`.`banner_to_date` >= 1740529185 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 13
      • 3: 1740529185
      • 4: 1740529185
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 13 and `b`.`banner_from_date` <= 1740529185 and `b`.`banner_to_date` >= 1740529185 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.14msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 13
      • 3: 1740529185
      • 4: 1740529185
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='c4e48aacb79486f86e8c5d1dbf1e2af3'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLangArticle
    2MultiLangArticle.php#?
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        eGHfKdSIR3bQ5z50AB3LBeDI3n2qlThmDRXwOMYs
        uc_cart_id
        c4e48aacb79486f86e8c5d1dbf1e2af3
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/113506/cn" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/113506/cn
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IitaeWNLUXQzbU1XYnFjSG0yampTcEE9PSIsInZhbHVlIjoiZGZTQlFBTW5IRk5sbjRkT3UwVkRINDU1MVJtRWgzTTNLRnV0THltUFNjND0iLCJtYWMiOiIwM2UxNzc0ZmUyNDYzMGMwOTUxMDg0Mzg3NWFiNDI5MGIwMzVmNTk4NzVhMDYyZjUyYWZlNjJiOGVlYjIyMTcxIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IitaeWNLUXQzbU1XYnFjSG0yampTcEE9PSIsInZhbHVlIjoiZGZTQlFBTW5IRk5sbjRkT3UwVkRINDU1MVJtRWgzTTNLRnV0THltUFNjND0iLCJtYWMiOiIwM2UxNzc0ZmUyNDYz" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 26 Feb 2025 00:19:45 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImFkSmk4S0RZRW5teCtGVGU3dmhBVEE9PSIsInZhbHVlIjoiUVFadGl1bFBXeENMQWUveXJ6eDhyM3ZlWHpJbDFtMjJ1RllKdFYwS0c2M0daWDEyRk9uN1ZnZlVQa2s5eW1udmlxdGhQS1FETnVwSU8wUktZQllkSWd1MGthSUJBMFdUOGR4bEcvR3R0YUZIWTBQZDVWaGtmeFBYRkU2MXRZd2wiLCJtYWMiOiJkMjYyNmQwOWRjYTBkYWU1MGM4NzFjMzM1MGJiMmJhNzBhOGM2OWNiNzk2OGU1MjBlNWQxMTQ5MzRhYzc4NDBiIiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 12:19:45 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImFkSmk4S0RZRW5teCtGVGU3dmhBVEE9PSIsInZhbHVlIjoiUVFadGl1bFBXeENMQWUveXJ6eDhyM3ZlWHpJbDFtMjJ1RllKdFYwS0c2M0daWDEyRk9uN1ZnZlVQa2s5eW1udmlxdGhQS" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZWZlhDdjQzZGUwNStBbGF6OS93R1E9PSIsInZhbHVlIjoieVozSGc2aEpSZEpuZmhXSDZnazUycTU4S1A2YVFZazZROVhnWmFDT2lBQ3RlL3R2em9VR1VsVmVJM1JyQTFDSVowcU9wSkZCY056ZVp4c2dHcUprVHlmaFora2pJeU8xY2FaL0N4K3NuKzNZaXprUXdhenFYeXlkRU0xTlZWRlQiLCJtYWMiOiIwZGRiNzAzYmRkYjEyNTIwN2MzZjVmZGI4NDg4YTAxYzg3ZjEyYmZkZDI1YmI5YWQ2NzEzY2E5M2Y4MmFkMWM4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjZWZlhDdjQzZGUwNStBbGF6OS93R1E9PSIsInZhbHVlIjoieVozSGc2aEpSZEpuZmhXSDZnazUycTU4S1A2YVFZazZROVhnWmFDT2lBQ3RlL3R2em9VR1VsVmV" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImFkSmk4S0RZRW5teCtGVGU3dmhBVEE9PSIsInZhbHVlIjoiUVFadGl1bFBXeENMQWUveXJ6eDhyM3ZlWHpJbDFtMjJ1RllKdFYwS0c2M0daWDEyRk9uN1ZnZlVQa2s5eW1udmlxdGhQS1FETnVwSU8wUktZQllkSWd1MGthSUJBMFdUOGR4bEcvR3R0YUZIWTBQZDVWaGtmeFBYRkU2MXRZd2wiLCJtYWMiOiJkMjYyNmQwOWRjYTBkYWU1MGM4NzFjMzM1MGJiMmJhNzBhOGM2OWNiNzk2OGU1MjBlNWQxMTQ5MzRhYzc4NDBiIiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 12:19:45 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImFkSmk4S0RZRW5teCtGVGU3dmhBVEE9PSIsInZhbHVlIjoiUVFadGl1bFBXeENMQWUveXJ6eDhyM3ZlWHpJbDFtMjJ1RllKdFYwS0c2M0daWDEyRk9uN1ZnZlVQa2s5eW1udmlxdGhQS" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZWZlhDdjQzZGUwNStBbGF6OS93R1E9PSIsInZhbHVlIjoieVozSGc2aEpSZEpuZmhXSDZnazUycTU4S1A2YVFZazZROVhnWmFDT2lBQ3RlL3R2em9VR1VsVmVJM1JyQTFDSVowcU9wSkZCY056ZVp4c2dHcUprVHlmaFora2pJeU8xY2FaL0N4K3NuKzNZaXprUXdhenFYeXlkRU0xTlZWRlQiLCJtYWMiOiIwZGRiNzAzYmRkYjEyNTIwN2MzZjVmZGI4NDg4YTAxYzg3ZjEyYmZkZDI1YmI5YWQ2NzEzY2E5M2Y4MmFkMWM4IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjZWZlhDdjQzZGUwNStBbGF6OS93R1E9PSIsInZhbHVlIjoieVozSGc2aEpSZEpuZmhXSDZnazUycTU4S1A2YVFZazZROVhnWmFDT2lBQ3RlL3R2em9VR1VsVmV" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "eGHfKdSIR3bQ5z50AB3LBeDI3n2qlThmDRXwOMYs" "uc_cart_id" => "c4e48aacb79486f86e8c5d1dbf1e2af3" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/113506/cn" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-26 00:19:45GET/article/113506/cn414413