摘要
N6-甲基腺苷 (m6A) 修饰控制多方面的 RNA 代谢,是人类转录组上分布最广泛的修饰之一,包括非编码 RNA (ncRNA)。之前将 ncRNA 视为“垃圾”转录产物的概念已经演变为 ncRNA 是决定特定生物过程和细胞命运的功能调节分子的概念。 m6A 修饰和 ncRNA 的失调与人类致癌作用的发展有关。据报道,某些类型的 ncRNA 对 m6A 机制发挥调节作用。然而,仍然需要更好地了解 m6A 修饰与癌症中 ncRNA 之间的关系。本综述讨论了 m6A 修饰和 ncRNA 之间的相互作用及其对人类癌症发展的影响。我们总结了 m6A-ncRNA 网络对癌症诊断和治疗的临床意义,并提出了在该研究领域仍未得到解答的具有挑战性的问题。了解 m6A 修饰和 ncRNA 之间的复杂协调将有助于指导治疗干预的发展。
关键词: N6-甲基腺苷、miRNA、LncRNA、CircRNA、PiRNA、非编码RNA、癌症。
图形摘要
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