摘要
类黄酮是大量存在于植物中的色烯类似物。 发现天然类黄酮结构一直很有趣,因为包括人类在内的生物经常通过许多饮食接触这些化合物。 迄今为止,已经对具有多种生物学作用的黄酮类化合物进行了大量研究。 获得的活性结果,特别是关于黄酮类化合物对阿尔茨海默病 (AD) 的各种经过验证和未经验证的靶标的影响,使这些化合物成为有希望直接用于临床试验或用作基于黄酮类化合物的重要支架的药物。 药物设计研究。 尽管有许多关于黄酮类化合物对 AD 的治疗和保护作用的评论文章,但在这篇评论中,黄酮类化合物对整个 AD 中发生的线粒体功能障碍的影响已经与其结构组织相伴随。
关键词: 类黄酮、阿尔茨海默病、线粒体功能障碍、活性氧、β-淀粉样蛋白、色烯类似物。
图形摘要
Current Drug Targets
Title:Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction
Volume: 22 Issue: 14
关键词: 类黄酮、阿尔茨海默病、线粒体功能障碍、活性氧、β-淀粉样蛋白、色烯类似物。
摘要: Flavonoids are chromene analogues abundantly found in plants. It has always been of interest to discover natural flavonoid structures, since living things, including humans, are routinely exposed to these compounds through many dietaries. So far, numerous studies have been conducted on flavonoids with diverse biological actions. The activity results obtained, particularly regarding the effects of flavonoids on various validated and non-validated targets of Alzheimer’s Disease (AD), make these compounds promising agents either to be directly employed in clinical trials or to be utilized as important scaffolds for flavonoid-based drug design studies. Although there are many review articles on the treatment and protective effects of flavonoids on AD, within this review, the effects of flavonoids on mitochondrial dysfunction developing throughout AD have been presented concomitant to their structural organization.
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Cite this article as:
Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450122666210120144921
DOI https://dx.doi.org/10.2174/1389450122666210120144921 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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