摘要
三维 (3D) 打印是一种很有前途的方法,可用于任何材料的快速原型制作和制造。它类似于影印或打印,其中新材料像它们的母组件一样在层 (3D) 上形成。随着 1980 年代的发展和进步,其在医药方面的应用仍然有限。它已成为过去十年中最具创新性和影响力的工具之一,作为开发剂型的技术。 3D 打印生产用于根据特定患者需求进行精确测量的药物的潜力已经显示出将个性化药物开发为新型剂型的可能性。这一突破使人们能够清楚地了解不同形状、尺寸、表面的剂量结构,以及通过使用此类设计条件递送它们的相关挑战。在药物中正确利用 3D 压印存在不同的困难,这对该技术的范围有很大影响。制药行业使用的 3D 打印技术领域的最新进展主要集中在用于制造不同剂型的不同技术上。美国食品和药物管理局 (FDA) 最近批准了第一个 3D 处方,这凸显了 3D 打印在药品供应领域的创新可能性。该分析评估了 3D 打印进步的可能性,特别是在定制处方领域。该技术可被视为按需生产的未来低成本固体剂型,有助于最大程度地减少因过量服用引起的副作用。
关键词: 3D 打印、熔融沉积成型、喷墨打印、立体光刻、个性化药物、光聚合。
图形摘要
Current Drug Targets
Title:3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges
Volume: 22 Issue: 16
关键词: 3D 打印、熔融沉积成型、喷墨打印、立体光刻、个性化药物、光聚合。
摘要: Three Dimensional (3D) printing is a promising method for quick prototyping and manufacturing of any material. It is similar to photocopy or printing, where the new materials are formed on layers (3D) like their mother component. Following its growth and advancement in the 1980s, its application in pharmaceuticals is still limited. It has become one of the most innovative and influential tools serving as a technology for developing dosage forms from the last decade. The potential of 3D printing to produce drugs for precise measurement customized to specific patients' needs has shown the possibility of developing personalized medicines to novel dosage forms. The breakthrough allows the clear perception of the dosage structures on different shapes, sizes, surfaces and the associated challenges in delivering them by using such designed conditions. There are different difficulties related to the correct utilization of 3D imprinting in the pharmaceuticals, which have a strong impact on the scope of this technology. Recent advancements in the field of 3D printing technology used in the pharmaceutical industry mainly focused on different techniques for the fabrication of different dosage forms. The Food and Drug Administration's (FDA) recent approval of the first 3D prescription highlights possibilities for 3D printing innovation in the field of pharmaceutical drug supply. This analysis assesses 3D printing advancement possibilities, particularly in the area of custom prescriptions. This technology can be regarded as the future produced on demand, low-cost solid dosage forms and helps minimize side effects due to overdose.
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Cite this article as:
3D Printing Technology in Pharmaceutical Dosage Forms: Advantages and Challenges, Current Drug Targets 2021; 22 (16) . https://dx.doi.org/10.2174/1389450122666210120142416
DOI https://dx.doi.org/10.2174/1389450122666210120142416 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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