Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis

doi:10.2174/1389450122666210120141546
摘要

癌症是由基因组变化引起的遗传疾病；然而，表观遗传改变在肿瘤发生和癌症进展过程中与这些变化协同作用。表观遗传变异作为肿瘤进展、转移和治疗抗性的重要调节因子而受到越来越多的关注。 CpG 岛的异常 DNA 甲基化是各种肿瘤抑制基因的表观遗传介导的基因沉默的中心事件。 DNA 甲基转移酶 1 (DNMT1) 主要在细胞增殖中半甲基化 DNA 底物上的 CpG 岛上发生甲基化。 DNMT1 已被证明在各种癌症类型中过表达，并表现出促进肿瘤的潜力。 DNMT1 靶向癌症治疗的主要缺点是核苷和非核苷类 DNMT1 抑制剂引起的不良反应。本文重点介绍了各种 microRNA (miRNA) 对 DNMT1 的调节，这些 microRNAs 可能被指定为未来的 DNMT1 调节剂，并重点介绍了 DNMT1 如何调节参与肿瘤抑制的各种 miRNA。重要的是，本综述探讨了 DNMT1 和某些 miRNA 之间相互抑制在致瘤潜力中的作用。因此，本综述旨在利用某些 miRNA 与传统的 DNMT1 抑制剂结合作为一种新型癌症疗法，提出一种有效且具有战略意义的方法。还确定了选择与 DNMT1 调控相关的 miRNA 候选物，这些候选物不仅可以作为癌症诊断和预后的潜在生物标志物，还可以预测癌细胞中异常甲基化活性的存在。
关键词: DNA 甲基转移酶、DNMT1、表观遗传学、miRNA、癌症、癌症治疗。
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图形摘要

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DOI https://dx.doi.org/10.2174/1389450122666210120141546	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592
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肿瘤发生过程中 DNA 甲基转移酶 1 和 microRNA 之间的相互作用

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肿瘤发生过程中 DNA 甲基转移酶 1 和 microRNA 之间的相互作用

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