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Review Article

他汀类药物在新发糖尿病中的作用：根本原因、涉及的机制和应对策略

卷 22, 期 10, 2021

发表于: 20 January, 2021

页: [1121 - 1128] 页: 8

弟呕挨: 10.2174/1389450122666210120125945

价格: $65

摘要

他汀类药物通过事件的一级和二级预防改变了心血管疾病的治疗。 尽管他汀类药物治疗心血管疾病取得了成功，但某些临床试验、评论和荟萃分析指出他汀类药物有诱发糖尿病的倾向。 强化他汀类药物治疗或糖尿病患者的风险进一步增加。 尚未确定诱导糖尿病状况的适当机制。 他汀类药物与β细胞参与胰岛素分泌和外周细胞参与胰岛素抵抗已被广泛研究和确定。 本综述提供了对他汀类药物诱导的糖尿病的最新认识的更新。 这涵盖了他汀类药物的起源、它们的发展、解释葡萄糖稳态不良影响的可能机制，以及可能的治疗目标。

关键词: 他汀类药物、糖尿病、代谢综合征、高胆固醇血症、药物性糖尿病、胆固醇。

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