SET Protein in Cancer: A Potential Therapeutic Target

Title:SET Protein in Cancer: A Potential Therapeutic Target

Volume: 21 Issue: 16

Author(s): Xinjie Liang, Xuefei Bao*Guoliang Chen*

Affiliation:

• Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016,China

• Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016,China

Keywords: SET, oncoprotein, dysregulation, cancer, prognosis, resistance, inhibitors.

Abstract: SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several inhibitors are being developed for clinical trials. In this review, the physiological and pathological functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges involved with translating SET inhibitors into bona fide therapeutic options.

Cite this article as:

Liang Xinjie , Bao Xuefei*, Chen Guoliang*, SET Protein in Cancer: A Potential Therapeutic Target, Mini-Reviews in Medicinal Chemistry 2021; 21 (16) . https://dx.doi.org/10.2174/1389557521666210114163318