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ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

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Research Article

Epidemiological Characteristics of 64 Covid-19 Patients in Errachidia Province (Darâa-Tafilalet region), Morocco: A Retrospective Analysis

Author(s): Mourad Akdad, Youness Algharrass, Hafid Talha, Abdelaadim Babakhouya, Mohammed Ajebli, Ahlam Ech-cherrate and Mohamed Eddouks*

Volume 16, Issue 3, 2021

Published on: 14 January, 2021

Page: [294 - 302] Pages: 9

DOI: 10.2174/1574887116666210114161633

Price: $65

Abstract

Background: At the time of writing this paper, no data was available for the clinical and epidemiological characteristics of African patients with COVID-19. Herein, we profiled retrospectively the epidemiological characteristics (clinical, laboratory, radiological, treatment, and clinical outcomes) of 64 confirmed cases of COVID-19 in the Regional Hospital Center (RHC) of Errachidia in Morocco. The aim of this study was to analyze the epidemiological characteristics and laboratory Findings of Covid-19 patients in Errachidia Province, Morocco.

Methods: This is a retrospective single-center study that included all COVID-19 confirmed patients (died or discharged) hospitalized in the Regional Center of Errachidia, Morocco, between March 20, 2020 and May 23, 2020. Patients were confirmed by real-time RT-PCR and epidemiological, demographic, clinical, laboratory, treatment, and outcomes of patients were extracted manually from patient’s medical records.

Results: In a total of 64 patients with COVID-19, 60.9% of patients were men, with a mean age of 41.5 years (SD 18.62). At the admission, 38 patients were asymptomatic (59.4%), and 58 (90.6%) were clinically classified as being in a benign state. Chronic illnesses were the most comorbidities observed, including diabetes with 8 cases (12.5%), hypertension 3 cases (4.7%), and hyperlipidemia 1 patient (1.6%). The main symptoms were cough 15 (23.4%), fever 10 (15.6), diarrhea 8 (12.5%), headache 5 (7.8%), and sore throat 5 (7.8%). Only 7 patients (10.9%) had lung lesions, and lymphopenia was present in only 7 patients (11.1%). The median duration of viral shedding was 14.5 days (9-22). Concerning deceased cases, they were elderly subjects aged 69.75 years, and they have presented dyspnea, breathing problems, and respiratory distress as specific symptoms. In addition, an increase of the medians of serum AST, CRP, and glucose levels was noticed in this group. During hospitalization, they presented acute respiratory distress syndrome (ARDS), and they were transferred to intensive care before they died.

Conclusion: This study revealed that covid-19 infection often appeared in a benign form in the studied population (90.6% in this study). This finding may incriminate the implication of some protective parameters such as genetic, nutritional or other factors in the Moroccan population.

Keywords: COVID-19, coronavirus, morocco, epidemiological, errachidia, darâa-tafilalet.

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[1]
Flaxman S, Mishra S, Gandy A, et al. Imperial College COVID-19 Response Team. Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe. Nature 2020; 584(7820): 257-61.
[http://dx.doi.org/10.1038/s41586-020-2405-7] [PMID: 32512579]
[2]
Plaçais L, Richier Q. COVID-19: Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up- to-date review at the heart of the pandemic. Rev Med Interne 2020; 41(5): 308-18.
[http://dx.doi.org/10.1016/j.revmed.2020.04.004] [PMID: 32334862]
[3]
Lovato A. Clinical presentation of COVID-19: A systematic review focusing on upper airway symptoms. Ear Nose Throat J 2020; 99(9): 569-76.
[4]
Du Y, Tu L, Zhu P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan. A retrospective observational study. Am J Respir Crit Care Med 2020; 201(11): 1372-9.
[http://dx.doi.org/10.1164/rccm.202003-0543OC] [PMID: 32242738]
[5]
Chen T, Dai Z, Mo P, et al. Clinical Characteristics and Outcomes of Older Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Single-Centered, Retrospective Study. J Gerontol A Biol Sci Med Sci 2020; 75(9): 1788-95.
[http://dx.doi.org/10.1093/gerona/glaa089] [PMID: 32279081]
[6]
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirusdisease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020; 180(7): 934-43.
[http://dx.doi.org/10.1001/jamainternmed.2020.0994] [PMID: 32167524]
[7]
Sun H, Ning R, Tao Y, et al. Risk factors for mortality in 244 older adults with COVID-19 in Wuhan, China: a retrospective study. J Am Geriatr Soc 2020; 68(6): E19-23.
[http://dx.doi.org/10.1111/jgs.16533] [PMID: 32383809]
[8]
Burke RM, Midgley CM, Dratch A, et al. Active monitoring of persons exposed to patients with confirmed COVID-19 — United States, January–February 2020. MMWR Morb Mortal Wkly Rep 2020; 69(9): 245-6.
[http://dx.doi.org/10.15585/mmwr.mm6909e1] [PMID: 32134909]
[9]
Ong SWX, Tan YK, Chia PY, et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA 2020; 323(16): 1610-2.
[http://dx.doi.org/10.1001/jama.2020.3227] [PMID: 32129805]
[10]
Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med 2020; 172(9): 577-82.
[http://dx.doi.org/10.7326/M20-0504] [PMID: 32150748]
[11]
Liu Y, Yan LM, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis 2020; 20(6): 656-7.
[http://dx.doi.org/10.1016/S1473-3099(20)30232-2] [PMID: 32199493]
[12]
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054-62.
[http://dx.doi.org/10.1016/S0140-6736(20)30566-3] [PMID: 32171076]
[13]
Mizumoto K, Kagaya K, Zarebski A, Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Euro Surveill 2020; 25(10): 2000180.
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.10.2000180] [PMID: 32183930]
[14]
Hu Z, Song C, Xu C, et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Sci China Life Sci 2020; 63(5): 706-11.
[http://dx.doi.org/10.1007/s11427-020-1661-4] [PMID: 32146694]
[15]
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382(18): 1708-20.
[16]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[17]
Li B, Jin X, Zhang T, et al. Comparison of cardiovascular metabolic characteristics and impact on COVID-19 and MERS. Eur J Prev Cardiol 2020; 27(12): 1320-4.
[http://dx.doi.org/10.1177/2047487320925218] [PMID: 32423251]
[18]
Phoswaa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19?. Eur J Obstet Gynecol Reprod Biol 2020.
[19]
Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun 2020; 109: 102433.
[http://dx.doi.org/10.1016/j.jaut.2020.102433] [PMID: 32113704]
[20]
Li M, Chen L, Zhang J, Xiong C, Li X. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One 2020; 15(4): e0230295.
[http://dx.doi.org/10.1371/journal.pone.0230295] [PMID: 32298273]
[21]
Zeng L, Xia S, Yuan W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates bornto mothers with COVID-19 in Wuhan, China. JAMA Pediatr 2020; 174(7): 722-5.
[http://dx.doi.org/10.1001/jamapediatrics.2020.0878] [PMID: 32215598]
[22]
Yang P, Wang P, Song Y, Zhang A, Yuan G, Cui Y. A retrospective study on the epidemiological characteristics and establishment of an early warning system of severe COVID-19 patients. J Med Virol 2020; 92(10): 2173-80.
[http://dx.doi.org/10.1002/jmv.26022] [PMID: 32410285]
[23]
Huang R, Zhu L, Xue L, et al. Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study. PLoS Negl Trop Dis 2020; 14(5): e0008280.
[http://dx.doi.org/10.1371/journal.pntd.0008280] [PMID: 32384078]
[24]
Wang L, Li X, Chen H, et al. Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China. Am J Nephrol 2020; 51(5): 343-8.
[http://dx.doi.org/10.1159/000507471] [PMID: 32229732]
[25]
Arentz M, Yim E, Klaff L, et al. Characteristicsoutcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA 2020; 323(16): 1612-4.
[http://dx.doi.org/10.1001/jama.2020.4326] [PMID: 32191259]
[26]
Pan Y, Ye G, Zeng X, et al. Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia? Clin Transl Med 2020; 10(1): 161-8.
[http://dx.doi.org/10.1002/ctm2.23] [PMID: 32508038]
[27]
Mo P, Xing Y, Xiao Y, et al. Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clin Infect Dis 2020; 2020: ciaa270.
[28]
Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol 2020; 109(5): 531-8.
[http://dx.doi.org/10.1007/s00392-020-01626-9] [PMID: 32161990]
[29]
Mubagwa K. Cardiac effects and toxicity of chloroquine: a short update. Int J Antimicrob Agents 2020; 56(2): 106057.
[http://dx.doi.org/10.1016/j.ijantimicag.2020.106057] [PMID: 32565195]
[30]
Martinez-Gonzalez MA, Martín-Calvo N. Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables. Curr Opin Clin Nutr Metab Care 2016; 19(6): 401-7.
[http://dx.doi.org/10.1097/MCO.0000000000000316] [PMID: 27552476]
[31]
Butler MJ, Barrientos RM. The impact of nutrition on COVID-19 susceptibility and long-term consequences. Brain Behav Immun 2020; 87: 53-4.
[http://dx.doi.org/10.1016/j.bbi.2020.04.040] [PMID: 32311498]

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