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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

同性和异性关系中老年人神经认知下降的比较

卷 17, 期 12, 2020

页: [1102 - 1114] 页: 13

弟呕挨: 10.2174/1567205018666210114111556

价格: $65

摘要

背景：性少数人群的健康状况不佳，加重了护理需求和阿尔茨海默氏病（AD）等慢性病的症状，对他们的健康（尤其是老年人）产生了不利影响。性少数人群中由于AD引起的神经认知下降仍未得到充分研究。但是，处于恋爱关系中可以减轻经历认知障碍的风险。 目的：本研究的目的是调查性少数人群的认知能力下降和脑萎缩是否可能有所不同。 方法：本研究的临床数据选自国家阿尔茨海默氏症协调中心的统一数据集和在14个阿尔茨海默氏症疾病中心收集的结构性MRI数据。确定了包括同性关系中的20位AD患者和20名健康对照（HC）在内的80名参与者，并将其与异性关系中的参与者组（20位AD和20 HC）进行了匹配。诊断和关系的影响在所有措施上进行了调查。 结果：在任何变量上均未发现按诊断的相互作用。但是，事后分析显示，异性恋人群的灰质萎缩主要发生在中颞区。在同性人群中，萎缩也扩展到额额前和扣带状区域。仅在同性组中，神经精神症状的严重程度与前额叶和岛/颞区的体积相关。 结论：AD引起的神经认知功能下降可能在个体中表达类似，而与关系类型无关，这表明关系状态具有保护作用。然而，同性人群似乎更可能经历至少一种神经精神症状，并且萎缩延伸至额缘区域。

关键词: 阿尔茨海默氏病，神经变性，婚姻关系，性少数，神经精神症状，认知。

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