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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

健忘性轻度认知障碍患者的颈动脉僵硬度和脑血流量

卷 17, 期 12, 2020

页: [1115 - 1125] 页: 11

弟呕挨: 10.2174/1567205018666210113155646

价格: $65

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摘要

背景：中央动脉僵硬是与年龄相关的认知障碍和阿尔茨海默氏病（AD）的新兴危险因素。然而，潜在的病理生理机制仍不清楚。 目的：我们检验了以下假设：在AD的前驱阶段轻度认知障碍（MCI）患者中，颈动脉僵硬度与脑血流量（CBF）降低和脑血管阻力（CVR）升高有关。 方法：对54例失忆性MCI患者和24名年龄和性别与MCI患者相似的认知正常受试者（CN）进行超声和压平眼压计测量CBF和颈动脉β-刚度指数。将总CBF量作为来自颈内动脉和椎动脉的CBF的总和，除以总脑组织质量（通过MRI评估）即可获得标准化CBF（nCBF）。 结果：相对于CN受试者，MCI患者的nCBF较低（53.3±3.2 vs 50.4±3.4 mL / 100 g / min，P <0.001）和CVR较高（0.143±0.019 vs 0.156±0.023 mmHg / mL / min，P < 0.015）。多元线性回归分析表明，nCBF与颈动脉β-刚度指数呈负相关（B = -0.822，P <0.001）。在调整年龄，性别，体重指数和MCI状态后，CVR与颈动脉收缩压呈正相关（B = 0.001，P <0.001）。 结论：这些发现表明，MCI伴颈动脉搏动增加的患者，颈动脉僵硬可能至少部分地导致nCBF降低和CVR升高。

关键词: 轻度遗忘性认知障碍，颈动脉僵硬，脑灌注不足，脑血管阻力， 搏动性脑血流，经颅多普勒，超声检查。

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