摘要
补体成分1,q亚组分结合蛋白(C1QBP/gC1q-R/p32/HABP1/TAP/YBAP1)是一种普遍存在的多功能蛋白。由于其N端线粒体定位信号,C1QBP主要位于线粒体,在细胞表面、细胞核、细胞质、细胞外间隙等不同亚细胞室中也有发现。据报道,C1QBP与多种具有明显不相关功能的蛋白质相互作用。C1QBP也被观察到与透明质酸和RNA相互作用。这些研究表明C1QBP同时具有线粒体和线粒体外功能。许多结合蛋白的C1QBP结合位点位于这些分子的基本和内在无序区域,这与C1QBP作为分子伴侣的假设是一致的。C1QBP在各种类型的人类癌症中表达升高,包括乳腺癌。此外,基于使用癌细胞系和异种移植模型进行的功能丧失和功能获得的研究,它已经涉及到癌细胞的发展、进展和转移。因此,C1QBP可能是乳腺癌治疗的一个分子靶点。由于C1QBP是一个潜在的治疗靶点,使用抗体、肿瘤归巢肽(如LyP-1)和靶向C1QBP的小分子的研究值得进一步开展。
关键词: C1QBP
Current Medicinal Chemistry
Title:Role of C1QBP/p32 and its Therapeutic Potential in Breast Carcinoma and other Cancers
Volume: 28 Issue: 25
关键词: C1QBP
摘要: The complement component 1, q subcomponent binding protein (C1QBP/gC1q-R/p32/HABP1/TAP/YBAP1), is a ubiquitous, multifunctional protein. C1QBP localizes mainly to mitochondria due to its N-terminal mitochondrial localization signal, but it can also be found in different subcellular compartments including the cell surface, nucleus, cytoplasm, and extracellular space. C1QBP has been reported to interact with a variety of proteins that have apparently unrelated functions. C1QBP has also been observed to interact with hyaluronic acid and RNA. These findings suggest that C1QBP has both mitochondrial and extramitochondrial functions. The C1QBP binding sites of many partner proteins are located within basic and intrinsically disordered regions of these molecules, consistent with the hypothesis that C1QBP functions as a molecular chaperone. C1QBP expression is elevated in various types of human cancers, including breast cancer. Moreover, it has been implicated in the development, progression, and metastasis of cancer cells based on loss-of-function and gain-of-function studies using cancer cell lines and xenograft models. Hence C1QBP could be a molecular target in breast cancer therapy. Studies using antibodies, tumor homing peptides such as LyP-1, and small molecules that target C1QBP warrant further investigation as C1QBP is a potential therapeutic target.
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Cite this article as:
Role of C1QBP/p32 and its Therapeutic Potential in Breast Carcinoma and other Cancers, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666201231124038
DOI https://dx.doi.org/10.2174/0929867328666201231124038 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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