对线粒体功能障碍及其在神经系统疾病中的影响的洞察

Title:An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases

Volume: 22 Issue: 14

关键词: 阿尔茨海默病、线粒体稳态、细胞凋亡、氧化应激、线粒体功能障碍、肌萎缩侧索硬化。

摘要: In the last few years, a massive increase in research has been observed that focuses on investigating the role of mitochondria in the pathogenesis of several neurodegenerative disorders. Mitochondria are vital cell organelles having important roles in different cellular processes, including energy production, calcium signaling, Reactive Oxygen Species (ROS) generation, apoptosis, etc. Therefore, healthy mitochondria are necessary for cell survival and functioning. It would seem feasible that mitochondrial dysfunction will have implications in various pathological conditions. A large body of evidence indicates the role of the mitochondrion as a potential key player in the loss or dysfunction of neurons in various neurodegenerative disorders. In this review, we provide an insight into mitochondrial dysfunction and its involvement in the pathology of several neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, Hypoxic- Ischemic Brain Injury, and many more.

Cite this article as:

An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450121999201230204050