摘要
前列腺癌是全球男性肿瘤相关死因的第五大原因。由于其潜伏期长,这种病理表现为一种理想的疾病类型的化学预防研究。在迄今为止被用于治疗前列腺癌的药物中,天然化合物白藜芦醇非常有前景。白藜芦醇是公认的一种化学预防剂,并被证明在几种肿瘤中能增强传统化疗药物的抗肿瘤活性,其中包括前列腺癌。本文综述了近五年来有关白藜芦醇及其衍生物作为前列腺癌抗转移药物的研究进展。此外,还提出了药物联合研究和纳米医学方法,以提高白藜芦醇的活性和克服转移缺陷。综述的最后一部分讨论了正在进行的含白藜芦醇的癌症患者临床试验。
关键词: 前列腺癌,白藜芦醇,二苯乙烯,转移,临床试验,药物联合。
Current Medicinal Chemistry
Title:Resveratrol and Prostate Cancer: The Power of Phytochemicals
Volume: 28 Issue: 24
关键词: 前列腺癌,白藜芦醇,二苯乙烯,转移,临床试验,药物联合。
摘要: Prostate cancer is the fifth cause of tumor-related deaths in man worldwide. Due to its long latency period, this pathology represents an ideal type of disease for chemopreventive studies. Among the drugs considered thus far for the treatment of prostate cancer, the natural compound resveratrol emerged as very promising. Resveratrol is widely recognized as a chemopreventive agent and was shown to potentiate the antitumor activity of conventional chemotherapeutics in several tumors, including prostate cancer. Here, we overview the literature of the last five years and summarize the recent achievements of resveratrol and its derivatives as antimetastatic agents in prostate cancer. Moreover, drug combination studies as well as nanomedicine approaches proposed to improve resveratrol activity and to overcome delivery drawbacks are addressed. The last part of the review discusses the clinical trials containing resveratrol ongoing on cancer patients.
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Cite this article as:
Resveratrol and Prostate Cancer: The Power of Phytochemicals, Current Medicinal Chemistry 2021; 28 (24) . https://dx.doi.org/10.2174/0929867328666201228124038
DOI https://dx.doi.org/10.2174/0929867328666201228124038 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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