Title:Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes
Volume: 22
Issue: 12
关键词:
抗菌素耐药性(AMR)、致病微生物、免疫治疗、联合治疗、噬菌体、CRISPR/Cas。
摘要: The major health-care burden for the developing world are infectious diseases where antimicrobial
agents prove to be the magical drugs to combat this. But the phenomenon of antimicrobial
resistance (AMR) represents a challenging global issue, which requires to be addressed effectively.
The antimicrobial treatment for the emerging multidrug-resistant bacterial (e.g. TB, Cholera) and
fungal (e.g. Candidiasis) infections is very limited, and there are multiple causes and reasons responsible
for the evolution of such resistance. Considering the critical issues of increasing AMR, there is
an urgent requirement of the identification, development, validation, and progression of novel strategies
and approaches that can easily be utilized for overcoming this serious issue. Immunotherapy
represents a significant way to improve host defenses and combat the issue of antimicrobial drug
resistance. Similarly, drug combination therapy represents another promising approach for reducing
the evolution of resistance and enhancing the longevity of the antimicrobial agents. Bacteriophage
therapy also acts as a novel therapeutic option to control the development of the multidrug resistance
(MDR) phenomenon. Besides, CRISPR, an innovative genome editing technology, offers multiple
applications to safeguard host defenses to overcome different resistance challenges. The novel approaches/
strategies like combination therapy, bacteriophage therapy, immunotherapy, and
CRISPR/Cas discussed here presents an overview of some of the novel strategies/approaches to be
adopted against the pathogenic microbes/microbial invasions along with advanced knowledge of different
drug resistance mechanisms adopted by the microbial pathogens to gain resistance against different
antimicrobial agents. Therefore, understanding the novel control plans/approaches and different
drug resistance mechanisms will help achieve the goals of the successful development of potential
antimicrobial drugs and their respective targets and eventually help curtail the problem of increasing
antimicrobial drug resistance menace in various human pathogenic microbes.
26