摘要
由结核分枝杆菌引起的结核病是世界上历史悠长的疾病之一,是世界十大死因之一,在传染病死亡率中排名第一,远远超过了可怕的疾病艾滋病。除此之外,脊柱结核是最常见的肺外结核,约占所有结核病例的1 - 3%,占肌肉骨骼感染的50%。然而,脊柱结核的耐药情况在世界范围内仍然具有挑战性。这种情况直接导致脊柱结核致残率高、治疗困难,给患者、家庭和社会带来沉重负担。因此,它一直是结核病研究者和脊柱医生关注的焦点之一。鉴于此,在本综述中,我们旨在概述目前的研究,重点是对当前脊柱结核药物使用的新理解以及治疗这一严重疾病广泛探索。
关键词: 肺结核,脊柱,药物,炎症,诊断,治疗。
Current Medicinal Chemistry
Title:Current Study of Medicinal Chemistry for Treating Spinal Tuberculosis
Volume: 28 Issue: 25
关键词: 肺结核,脊柱,药物,炎症,诊断,治疗。
摘要: Tuberculosis, caused by Mycobacterium tuberculosis, is one of the oldest diseases in the world and is one of the top ten causes of death in the world, ranking first mortality in infectious diseases, far beyond the frightening disease AIDS. Besides that, spinal tuberculosis is the most common form of extrapulmonary tuberculosis, accounting for approximately 1 to 3% of all tuberculosis cases, and accounting for 50% of musculoskeletal infections. However, the drug-resistant situation of spinal tuberculosis is still challenging world wide. This situation directly leads that spinal tuberculosis has a high disability rate and is difficult to treat, which causes a heavy burden to patients, families and society. Therefore, it has been one of the focuses of tuberculosis researchers and spine doctors. Considering that, in this review, we aim to overview the current studies that focused on the novel understanding of current spinal tuberculosis medicine usage and extensive explorations for treating this severe disease.
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Cite this article as:
Current Study of Medicinal Chemistry for Treating Spinal Tuberculosis, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666201222125225
DOI https://dx.doi.org/10.2174/0929867328666201222125225 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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