Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders

Title:Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders

Volume: 28 Issue: 29

Author(s): Sadra Samavarchi Tehrani, Reyhane Ebrahimi, Atiyeh Al-e-Ahmad, Ghodratollah Panahi, Reza Meshkani, Simin Younesi, Payam Saadat and Hadi Parsian*

Affiliation:

• Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran

Keywords: Competing endogenous RNAs (CeRNAs), MicroRNAs, Long non-coding RNAs, Pseudogenes, CircularRNAs, Neurological disorders.

Abstract: Neurological disorders (NDs) comprise a broad range of diseases affecting both central and peripheral nervous systems. These complex multifactorial diseases have a high rate of mortality all over the world, particularly in aged people. Today, new evidence drove our attention to the notable role of noncoding RNAs (ncRNAs) in the progression of NDs. Remarkably, recent studies showed that there are close communication networks among RNA transcripts such as mRNAs, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and pseudogenes for regulating each other’s expression through competing for shared sequences in microRNAs (miRs). This concept is a new area of ongoing research recognized as competing endogenous RNA (ceRNA) hypothesis. CeRNAs are novel regulatory molecules in a wide range of biological stages and pathological contexts. Indeed, the disruption of ceRNA networks (ceRNETs) may affect neural development genes and induce neuropathological changes leading to the development of NDs. Because of this, identifying the correlation of ceRNETs with NDs will open a new window for expanding our knowledge about this field of science, as well as creating novel roads for developing specific diagnostic biomarkers for NDs management. Owing to these unique features, exploring the exact role of ceRNAs is a hot topic in NDs investigations. Hence, in this review, we will summarize the evidence supporting ceRNETs in the regulation of NDs-related gene expression.

Cite this article as:

Tehrani Samavarchi Sadra , Ebrahimi Reyhane , Al-e-Ahmad Atiyeh , Panahi Ghodratollah , Meshkani Reza , Younesi Simin , Saadat Payam and Parsian Hadi *, Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders, Current Medicinal Chemistry 2021; 28 (29) . https://dx.doi.org/10.2174/0929867328666201217141837