从代谢网络中学习：精准医学的当前趋势和未来方向

Title:Learning from Metabolic Networks: Current Trends and Future Directions for Precision Medicine

Volume: 28 Issue: 32

关键词: 代谢网络、生化数据库、精准医学、组学数据、数学建模、机器学习、深度学习。

摘要:

Background: Systems biology and network modeling represent, nowadays, the hallmark approaches for the development of predictive and targeted-treatment based precision medicine. The study of health and disease as properties of the human body system allows the understanding of the genotype-phenotype relationship through the definition of molecular interactions and dependencies. In this scenario, metabolism plays a central role as its interactions are well characterized and it is considered an important indicator of the genotype- phenotype associations. In metabolic systems biology, the genome-scale metabolic models are the primary scaffolds to integrate multi-omics data as well as cell-, tissue-, condition- specific information. Modeling the metabolism has both investigative and predictive values. Several methods have been proposed to model systems, which involve steady-state or kinetic approaches, and to extract knowledge through machine and deep learning.

Methods: This review collects, analyzes, and compares the suitable data and computational approaches for the exploration of metabolic networks as tools for the development of precision medicine. To this extent, we organized it into three main sections: "Data and Databases", "Methods and Tools", and "Metabolic Networks for medicine". In the first one, we have collected the most used data and relative databases to build and annotate metabolic models. In the second section, we have reported the state-of-the-art methods and relative tools to reconstruct, simulate, and interpret metabolic systems. Finally, we have reported the most recent and innovative studies that exploited metabolic networks to study several pathological conditions, not only those directly related to metabolism.

Conclusion: We think that this review can be a guide to researchers of different disciplines, from computer science to biology and medicine, in exploring the power, challenges and future promises of the metabolism as predictor and target of the so-called P4 medicine (predictive, preventive, personalized and participatory).

Cite this article as:

Learning from Metabolic Networks: Current Trends and Future Directions for Precision Medicine, Current Medicinal Chemistry 2021; 28 (32) . https://dx.doi.org/10.2174/0929867328666201217103148