Abstract
In this study, 3-alkyl(aryl)-4-(4-ethylbenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5- ones 2 were synthesized as explained in the literature. Then, the Schiff bases 2 were treated with morpholine/ N-methylpiperazine/ 3-methylpiperidine/ 4-piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize novel Mannich bases 3, 4, 5, and 6 types, respectively. The structural analyses of 24 newly synthesized compounds were characterized using proton/ carbon 13 nuclear magnetic resonance (1H/ 13C-NMR), Infrared (IR) spectoscopic techniques. In addition, the antimicrobial activity of the compounds was determined on six bacteria by using the agar well diffusion method. The most effective results against gram positive and negative bacteria were observed in 6(a-d) and 6f compounds. Also, the antioxidant capacities of the substances were investigated by three different methods (DPPH, reducing power, metal chelation). All compounds 3-6(a-f) showed a metal chelating effect.
Keywords: Schiff bases, mannich bases, 4, 5-Dihydro-1H-1, 2, 4-triazol-5-one, antimicrobial activity, antioxidant activity, DPPH.
Graphical Abstract
Letters in Organic Chemistry
Title:Novel Mannich Base Derivatives: Synthesis, Characterization, Antimicrobial and Antioxidant Activities
Volume: 18 Issue: 10
Author(s): Gül Kotan*
Affiliation:
- Department of Chemistry, Kars Vocational School, Kafkas University, Kars,Turkey
Keywords: Schiff bases, mannich bases, 4, 5-Dihydro-1H-1, 2, 4-triazol-5-one, antimicrobial activity, antioxidant activity, DPPH.
Abstract: In this study, 3-alkyl(aryl)-4-(4-ethylbenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5- ones 2 were synthesized as explained in the literature. Then, the Schiff bases 2 were treated with morpholine/ N-methylpiperazine/ 3-methylpiperidine/ 4-piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize novel Mannich bases 3, 4, 5, and 6 types, respectively. The structural analyses of 24 newly synthesized compounds were characterized using proton/ carbon 13 nuclear magnetic resonance (1H/ 13C-NMR), Infrared (IR) spectoscopic techniques. In addition, the antimicrobial activity of the compounds was determined on six bacteria by using the agar well diffusion method. The most effective results against gram positive and negative bacteria were observed in 6(a-d) and 6f compounds. Also, the antioxidant capacities of the substances were investigated by three different methods (DPPH, reducing power, metal chelation). All compounds 3-6(a-f) showed a metal chelating effect.
Export Options
About this article
Cite this article as:
Kotan Gül *, Novel Mannich Base Derivatives: Synthesis, Characterization, Antimicrobial and Antioxidant Activities, Letters in Organic Chemistry 2021; 18 (10) . https://dx.doi.org/10.2174/1570178617999201216113719
DOI https://dx.doi.org/10.2174/1570178617999201216113719 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers