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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Recent Advances in C–H Activation and Functionalization of Quinazolinones/ Quinazolines

Author(s): N. Umadevi, G. Kumar, N.C. Gangi Reddy* and B.V. Subba Reddy*

Volume 25, Issue 5, 2021

Published on: 10 December, 2020

Page: [601 - 634] Pages: 34

DOI: 10.2174/1385272824999201210180732

Price: $65

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Abstract

This review summarizes the transition metal-catalyzed direct C–H functionalization of quinazolinones and quinazolines through C-C, C-N and C-O bond formations. It focuses mainly on the C-H (sp2 or sp3) bond arylation, amination, sulfamidation, acetoxylation, halogenation, annulation of quinazolinones and quinazolines. This review illustrates the scope of C-H activation and functionalization of various quinazolinone and quinazoline derivatives.

Keywords: Quinazolinones, quinazolines, arylation, amination, sulfamidation, acetoxylation, halogenation, C-H activation, insertion, metallocycles, transition metals, oxidative coupling, reductive elimination, regioselective, chemoselective, cross-couplings.

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