摘要
背景:阴道药物传递为有效的杀菌剂治疗提供了一个机会。然而,阴道的生理特性是一个挑战时,准备杀菌剂制剂的局部分娩,避免全身影响。 目的:综述阴道杀菌剂的最新进展,特别重视封装肽杀菌剂的纳米载体。该综述概述了使用肽类杀菌剂的杀菌、真菌、原生动物和病毒性阴道感染的局部治疗和预防策略。 方法:分析2015年以来在PubMed数据库上发表的科学文献和临床试验。 结果:肽杀菌剂用于阴道药物,作为预防和治疗几种传染病,特别是性传播感染的手段,这种肽基杀菌剂显然是合适的策略。它们与纳米技术给药系统的结合改善了局部肽的给药,同时避免了其降解和不良反应。迄今为止,只有少数聚合物和脂质纳米载体被用于肽杀菌剂阴道分娩。 结论:近年来,纳米技术与肽杀菌剂结合出现,阴道肽输送应用平台。通过阴道环或水凝胶传递肽的纳米结构系统被越来越多地被用作能够提供合适的药物传递的平台。然而,目前仍缺乏关于旨在将用于局部杀微生物剂传递的封装肽段的纳米载体的知识
关键词: 阴道杀菌剂、抗菌肽、纳米颗粒、阴道药物给药、聚合物纳米颗粒、脂质囊泡、性传播感染、性病。
Current Medicinal Chemistry
Title:Nanotechnology-Based Platforms for Vaginal Delivery of Peptide Microbicides
Volume: 28 Issue: 22
关键词: 阴道杀菌剂、抗菌肽、纳米颗粒、阴道药物给药、聚合物纳米颗粒、脂质囊泡、性传播感染、性病。
摘要:
Background: Vaginal drug delivery offers an opportunity for effective microbicide treatments. However, the physiological characteristics of the vagina represent a challenge when preparing microbicide formulations for local delivery that avoid systemic effects.
Objective: To review recent advances in vaginal microbicides placing special emphasis on nanocarriers that encapsulate peptide microbicides. The review includes an overview of local treatment and prevention strategies for bactericidal, fungal, protozoal and viral vaginal infections that use peptide microbicides.
Methods: Scientific literature and clinical trials published in the PubMed database since 2015 are analyzed.
Result: Peptide microbicides are used for vaginal drug delivery as a means of prevention and treatment of several infectious diseases, especially sexually transmitted infections, and it is clear that such peptide-based microbicides constitute a suitable strategy. Their combination with nanotechnological drug delivery systems improves local peptide administration while avoiding their degradation and adverse effects. To date, only a few polymeric and lipid-based nanocarriers have been used for peptide microbicide vaginal delivery.
Conclusion: The combination of nanotechnology and peptide microbicides has emerged over recent years, and different platforms are being used for vaginal peptide delivery. Nanostructured systems for peptide delivery via vaginal rings or hydrogels are increasingly used as platforms capable of providing suitable drug delivery. However, there is still a lack of knowledge about nanocarriers aimed at encapsulating peptides for local microbicide delivery.
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Cite this article as:
Nanotechnology-Based Platforms for Vaginal Delivery of Peptide Microbicides, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867328666201209095753
DOI https://dx.doi.org/10.2174/0929867328666201209095753 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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