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Review Article

遗传传递和基因治疗的进化时间表

卷 21, 期 2, 2021

发表于: 08 December, 2020

页: [89 - 111] 页: 23

弟呕挨: 10.2174/1566523220666201208092517

价格: $65

摘要

与遗传性疾病相关或与某些疾病风险升高相关的基因超过3500个。 作为小分子药物常规治疗的替代方法，基因治疗已成为一种有效的治疗方法，不仅可以缓解疾病，而且可以完全治愈疾病。 为了使这些治疗方案起作用，必须将旨在纠正患病遗传材料的基因或编辑工具有效地递送至靶位。 已经开发了许多技术来实现这一目标。 在本文中，我们系统地审查了各种基因传递和治疗方法，包括物理方法，化学和生化方法，病毒方法和基因组编辑。 我们讨论了他们的历史发现，机制，优势，局限性，安全性和观点。

关键词: 非病毒性、CPPs、病毒性、ZFNs、TALENs、CRISPR、基因治疗、基因传递、基因组编辑。

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图形摘要

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