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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

淀粉样蛋白-β肽和Tau蛋白的朊病毒性质：在神经外科手术干预期间是否存在传播阿尔茨海默氏病的风险？

卷 17, 期 9, 2020

页: [781 - 789] 页: 9

弟呕挨: 10.2174/1567205017666201204164220

价格: $65

摘要

最近的研究已经认识到参与阿尔茨海默病神经病理学的肽与朊蛋白之间的相似性。 Tau蛋白和淀粉样β肽代表了阿尔茨海默氏病发展的理论基础。 这些物质的传播和朊病毒疾病的发展可能存在共同的机制； 此推定是基于对几例无危险因素的个体的陈述，这些个体在神经外科手术后数十年发展为痴呆。 本文旨在介绍Aβ和Tau的作用，它们通过分子（体外），动物和动物体内的可用证据，介绍了AD参与的病理生理机制及其与朊病毒疾病感染机制的相似性。 支持这些疾病是否可能通过神经外科手术传播的争议，这可能构成广泛的公共卫生问题。

关键词: 传播，朊蛋白疾病，淀粉样β，Aβ，神经外科，脑淀粉样血管病，τ蛋白，阿尔茨海默病。

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