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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

A Review on Biological Properties and Synthetic Methodologies of Diarylpentadienones

Author(s): Maryam Aisyah Abdullah, Siti Munirah Mohd Faudzi* and Nadiah Mad Nasir

Volume 21, Issue 9, 2021

Published on: 03 December, 2020

Page: [1058 - 1070] Pages: 13

DOI: 10.2174/1389557520999201203213957

Price: $65

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Abstract

Medicinal chemists have continuously shown interest in new curcuminoid derivatives, diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia- Kocienski olefination have been utilised for the synthesis of these compounds. Diarylpentadienones possess a high potential as a chemical source for designing and developing new and effective drugs for the treatment of diseases, including inflammation, cancer, and malaria. In brief, this review article focuses on the broad pharmacological applications and the summary of the structure-activity relationship of molecules, which can be employed to further explore the structure of diarylpentadienone. The current methodological developments towards the synthesis of diarylpentadienones are also discussed.

Keywords: Diarylpentadienone, synthesis, catalysts, bioactivity, pharmacological activity, SAR.

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