摘要
幽门螺杆菌是世界上最常见的病原菌,约占世界人口的50%,引起胃腺癌、慢性胃炎、胃黏膜相关淋巴组织(MALT)淋巴瘤等重要疾病。近年来,各种研究报道幽门螺杆菌生物膜可能是根除该细菌感染的关键因素之一。生物膜抑制抗生素的渗透,增加外排泵和突变的表达,多重治疗失败和慢性感染。纳米粒子和天然产物可以通过破坏幽门螺杆菌的外层和抑制细菌的初始结合来破坏幽门螺杆菌的生物膜。此外,使用破坏细胞外聚合物物质的联合疗法减少了球菌形式的细菌和降解外基质中的多糖,从而增加了抗生素的渗透性和性能。不同的益生菌、抗菌肽、化学物质和多糖通过抑制幽门螺杆菌的粘附和定殖,可以防止该细菌形成生物膜。值得注意的是,以上许多都适用于酸性pH值,可用于治疗胃炎。因此,幽门螺杆菌的生物膜可能是导致该细菌感染无法根除的主要原因之一,抗生素无法破坏该生物膜。因此,有必要使用新的策略来防止复发和慢性感染通过抑制生物膜的形成。
关键词: 幽门螺杆菌,生物膜,胃炎,抗生素耐药性,新策略,维生素B12。
Current Molecular Medicine
Title:Helicobacter pylori Biofilm and New Strategies to Combat it
Volume: 21 Issue: 7
关键词: 幽门螺杆菌,生物膜,胃炎,抗生素耐药性,新策略,维生素B12。
摘要: Helicobacter pylori, the most frequent pathogen worldwide that colonizes around 50% of the world’s population, causes important diseases such as gastric adenocarcinoma, chronic gastritis, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. In recent years, various studies have reported that H. pylori biofilm may be one of the critical barriers to the eradication of this bacterial infection. Biofilms inhibit the penetration of antibiotics, increase the expression of efflux pumps and mutations, multiple therapeutic failures, and chronic infections. Nanoparticles and natural products can demolish H. pylori biofilm by destroying the outer layers and inhibiting the initial binding of bacteria. Also, the use of combination therapies destroying extracellular polymeric substances decreases coccoid forms of bacteria and degrading polysaccharides in the outer matrix that lead to an increase in the permeability and performance of antibiotics. Different probiotics, antimicrobial peptides, chemical substances, and polysaccharides by inhibiting adhesion and colonization of H. pylori can prevent biofilm formation by this bacterium. Of note, many of the above are applicable to acidic pH and can be used to treat gastritis. Therefore, H. pylori biofilm may be one of the major causes of failure to eradication of infections caused by this bacterium, and antibiotics are not capable of destroying the biofilm. Thus, it is necessary to use new strategies to prevent recurrent and chronic infections by inhibiting biofilm formation.
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Cite this article as:
Helicobacter pylori Biofilm and New Strategies to Combat it, Current Molecular Medicine 2021; 21 (7) . https://dx.doi.org/10.2174/1566524020666201203165649
DOI https://dx.doi.org/10.2174/1566524020666201203165649 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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