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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

前行动；对抗痴呆症发作和进展的综合策略

卷 17, 期 9, 2020

页: [790 - 804] 页: 15

弟呕挨: 10.2174/1567205017666201203085524

价格: $65

摘要

脑衰老和衰老相关的神经退行性疾病对全世界的卫生系统构成了重大挑战。 迄今为止，大多数旨在抵消与痴呆相关的行为和认知障碍的治疗方法都集中于解决该疾病的假定决定因素，例如β-淀粉样蛋白或tau蛋白。 相比之下，针对恢复或促进衰老的大脑的突触可塑性的药理干预措施的关注相对较少。 这篇综述将探讨和讨论最新的分子，结构/功能和行为证据，这些证据支持使用非药理学方法以及认知增强药物来对抗脑衰老和早期痴呆症。

关键词: 衰老，β-淀粉样蛋白，认知增强药物，痴呆，fMRI，超连通性，神经元储备，tau，兴奋性毒性，谷氨酸，认知刺激，运动。

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